Lou J, Zhang L & Zheng G
Advanced Therapeutics, 2019
DOI: 10.1002/adtp.201800128

Cancer immunotherapies can elicit long term, durable responses in only a fraction of patients. As such, there is a need to increase the number of patients who can benefit from cancer immunotherapies. By virtue of their versatility and nanoscale, nanoparticles have unique properties that can be exploited to enhance the efficacy of cancer immunotherapies. This review first outlines key concepts in nanotechnology and immunotherapy. Then, it highlights nanotechnology‚Äźmediated improvements to the efficacy of immune checkpoint inhibitors, cancer vaccines, and adoptive cellular therapies. Next, the insights derived from nanoparticle‚Äźmediated imaging of immune cells in both preclinical and clinical studies are reviewed. Afterwards, the roles of nanotechnology in combination therapies to augment antitumoral immunity are summarized. Finally, the challenges facing this emerging field combining nanotechnology with immunotherapies are discussed. Given the exciting, novel approaches that can arise from nanotechnology, there is great potential for nanotechnology to advance immunotherapies.