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Li H, Zhang Z, Blessington D, Nelson DS, Zhou R, Lund-Katz S, Chance B, Glickson JD & Zheng G Academic Radiology, 2004 Rationale and objectives: The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptorContinue Reading

Zheng G, Li H, Yang K, Blessington D, Licha K, Lund-Katz S, Chance B, Glickson JD Bioorganic & medicinal chemistry letters, 2002 DOI: 10.1016/s0960-894x(02)00193-2 For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moietyContinue Reading

Zheng G, Li H, Zhang M, Lund-Katz S, Chance B, Glickson JD Bioconjugate chemistry, 2002 DOI: 10.1021/bc025516h To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that thisContinue Reading