Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles

Yang M, Jin H, Chen J, Ding L, Ng KK, Lin Q, Lovell JF, Zhang Z & Zheng G
Small, 2011

High-density lipoprotein (HDL)-mimicking peptide–phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability of cholesterol-modified siRNA displayed by the nanoparticle results in the selective delivery of RNA interference (RNAi) to targeted cells. This provides a strategy to bypass endolysosomal trafficking, and makes HPPS a useful tool for therapeutic siRNA delivery.