2003

Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies

Chen Y, Zheng G, Zhang ZH, Blessington D, Zhang M, Li H, Liu Q, Zhou L, Intes X, Achilefu S, Chance B Optics letters, 2003 DOI: 10.1364/OL.28.002070 We present a high-sensitivity near-infrared optical imaging system for noninvasive cancer detection and localization based on molecularly labeled fluorescent contrast agents. This frequency-domainContinue Reading

Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters

Zhang M, Zhang Z, Blessington D, Li H, Busch TM, Madrak V, Miles J, Chance B, Glickson JD, Zheng G Bioconjugate chemistry, 2003 DOI: 10.1021/bc034038n To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized and evaluated in a 9L glioma ratContinue Reading