Zheng G, Chen J, Li H & Glickson, JD Proceedings of the National Academy of Sciences, 2005 We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated receptors. Multiple copiesContinue Reading

Li H, Marotta DE, Kim S, Busch TM, Wileyto EP & Zheng G Journal of Biomedical Optics, 2005 To improve the labeling efficiency of a low-density lipoprotein (LDL)-based photosensitizer (PS) for achieving high probe to protein payload, a tetra-tt-butyl silicon phthalocyanine bearing two oleate moieties at its axial positions, SiPcBOA,Continue Reading

Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD & Therien MJ Bioconjugate Chemistry, 2005 Meso-to-meso ethyne-bridged tris[(porphinato)zinc(II)] (PZn3) near-infrared (NIR) fluorophores (λemmax ∼800 nm) can be rendered sufficiently amphiphilic to enable their facile incorporation into the hydrophobic core of the apo form of low-density lipoprotein (apo-LDL).Continue Reading