2006

Targeted photodynamic therapy agent with a built-in apoptosis sensor for in vivo near-infrared imaging of tumor apoptosis triggered by its photosensitization in situ

Stefflova K, Chen J Li H & Zheng G Molecular Imaging, 2006 Imaging apoptotic cells or tissues after cancer therapy in situ would be a very useful tool for assessing proper treatment conditions and therapeutic outcome. By combining therapeutic and imaging functions, we have designed a multifunctional, membrane-permeable, and cancer-specificContinue Reading

Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents

Corbin IR, Li H, Chen J, Lund-Katz S, Zhou R, Glickson JD & Zheng G Neoplasia, 2006 Low-density lipoproteins (LDLs) are a naturally occurring endogenous nanoplatform in mammalian systems. These nanoparticles (22 nm) specifically transport cholesterol to cells expressing the LDL receptor (LDLR). Several tumors overexpress LDLRs presumably to provideContinue Reading

Photodynamic therapy agent with a built-in apoptosis sensor for evaluating its own therapeutic outcome in situ

Stefflova K, Chen J, Li H & Zheng G Journal of Medicinal Chemistry, 2006 Identifying the extent of apoptosis in cells or tissues after cancer therapy in real time would be a powerful firsthand tool for assessing therapeutic outcome. We combined therapeutic and imaging functions in one agent, choosing photodynamicContinue Reading