Song L, Li H, Sunar U, Chen J, Corbin I, Yodh AG, Zheng G International journal of nanomedicine, 2007 PMID: 18203443 Low density lipoproteins (LDLs) are naturally occurring nanoparticles that are biocompatible, biodegradable and non-immunogenic. Moreover, the size of LDL particle is precisely controlled (~22 nm) by its apoB-100 component,Continue Reading
Corbin IR, Chen J, Cao W, Li H, Lund-Katz S, Zheng G Journal of Biomedical Nanotechnology, 2007 DOI: 10.1166/jbn.2007.053 One of the greatest obstacles nanoscale drug delivery systems face is the high nonspecific uptake by the reticular endothelial system (RES). Currently, PEGylation is the method of choice to address thisContinue Reading
Chen J, Jarvi M, Lo P, Stefflova K, Wilson BC & Zheng G Photochemical and Photobiological Sciences, 2007 We recently introduced the concept of photodynamic molecular beacons (PMB) for selective control of photodynamic therapy (PDT). The PMB consists of a peptide linker that is sequence specific to a cancer-associated protease.Continue Reading
Corbin IR & Zheng G Nanomedicine, 2007 Evaluation of: Nikanjam M, Blakely EA, Bjornstad KA, Shu X, Budinger TF, Forte TK: Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. Int. J. Pharm. 3287, 86–94 (2007). Low-density lipoproteins have long been recognized as a viable nanocarrier forContinue Reading
Stefflova K, Chen J & Zheng G Frontiers in Bioscience, 2007 Molecular beacons are essentially all probes that illuminate particular cellular target or cells with similar characteristics. In this review we focus on those molecular beacons that use near-infrared fluorescence imaging (NIRF-I) to identify the unique cellular and metabolic markersContinue Reading
Chan J, Corbin IR, Li H, Cao W, Glickson JD & Zheng G Journal of the American Chemical Society, 2007 LDL particles are high-capacity nanocarriers with precisely controlled size and are naturally biocompatible, biodegradable, and nonimmunogenic. However, their utilities as drug carriers are limited by the narrow purview of LDLContinue Reading
Zheng G, Chen J, Stefflova K, Jarvi M, Li H & Wilson BC Proceedings of the National Academy of Sciences, 2007 Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus are useful tools for in vivo cancer imaging. Photodynamic therapyContinue Reading
Stefflova K, Li H, Chen J & Zheng G Bioconjugate Chemistry, 2007 We designed and synthesized a folate receptor-targeted, water-soluble, and pharmacomodulated photodynamic therapy (PDT) agent that selectively detects and destroys the targeted cancer cells while sparing normal tissue. This was achieved by minimizing the normal organ uptake (e.g., liverContinue Reading
Stefflova K, Chen J & Zheng G Current Medicinal Chemistry, 2007 Precisely localizing therapeutic agents in neoplastic areas would greatly improve their efficacy for killing tumor cells and reduce their toxicity to normal cells. Photodynamic therapy (PDT) is a promising cancer treatment modality, and near-infrared fluorescence imaging (NIRF-I) is aContinue Reading
