Zhang Z, Cao W, Jin H, Lovell JF, Yang M, Ding L, Chen J, Corbin I, Luo Q & Zheng G Angewandte Chemie International Edition, 2009 Getting straight to the point: A peptide–phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptakeContinue Reading

Cao W, Ng KK, Corbin I, Zhang Z, Ding L, Chen J & Zheng G Bioconjugate Chemistry, 2009 The syntheses of novel near-infrared (NIR) dyes with excellent optical properties in biological tissues have driven the continued improvement of fluorescence imaging of deeply seated tumors. Bacteriochlorophyll a (Bchl), a dye synthesizedContinue Reading

Chen J, Liu TWB, Wilson BC & Zheng G Bioconjugate Chemistry, 2009 We report the proof-of-principle concept for zipper molecular beacons (ZMB) comprising an asymmetrical polyarginine/polyglutamate electrostatic “zipper” hairpin-linked fluorophore−quencher pair. The objective is to balance maximal quenching efficiency and optimal two-step activation (protease cleavage/zipper dissociation), while enhancing target cellContinue Reading

Lovell JF, Chen J, Jarvi MT, Cao W, Allen AD, Liu Y, Tidwell TT, Wilson BC & Zheng G Journal of Physical Chemistry B, 2009 The development of activatable photodynamic therapy (PDT) has demonstrated a utility for effective photosensitizer quenchers. However, little is known quantitatively about Forster resonance energy transferContinue Reading

Lo P, Chen J, Stefflova K, Warren MS, Navab R, Bandarchi B, Mullins S, Tsao M, Cheng JD & Zheng G Journal of Medicinal Chemistry, 2009 Fibroblast activation protein (FAP) is a cell-surface serine protease highly expressed on cancer-associated fibroblasts of human epithelial carcinomas but not on normal fibroblasts, normalContinue Reading