Lin Q, Chen J, Jin H, Ng KK, Yang M, Cao W, Ding L, Zhang Z & Zheng G Nanomedicine, 2012 The main challenge for RNAi therapeutics lies in systemic delivery of siRNA to the correct tissues and transporting them into the cytoplasm of targeted cells, at safe, therapeutic levels.
Liu TW, MacDonald TD, Shi J, Wilson BC & Zheng G Angewandte Chemie International Edition, 2012 PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one-pot, high-yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity
Jin H, Chen J, Lovell JF, Zhang Z, Zheng G Israel Journal of Chemistry, 2012 DOI: 10.1002/ijch.201100054 The design and synthesis of new light‐activated contrast agents for theranostics (therapy/diagnosis) has the potential to facilitate multifunctional and improved personalized medicine. The use of light as a remote activation strategy provides spatial
Tam N, McVeigh P, MacDonald TD, Farhadi A, Wilson BC & Zheng G Bioconjugate Chemistry, 2012 A porphyrin–phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal
Roxin A & Zheng G Future Medicinal Chemistry, 2012 Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long-standing focus within peptide research is the creation of structurally constrained peptides generated through cyclization. Cyclization is
Huynh E, Lovell JF, Helfield BL, Jeon M, Kim C, Goertz DE, Wilson BC, & Zheng G Journal of the American Chemical Society, 2012 Porphyrin–phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell (“porshe”), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin–lipid
Roxin A, Chen J, Scully CC, Rotstein BH, Yudin AK & Zheng G Bioconjugate Chemistry, 2012 Here, we demonstrate a conjugation strategy whereby cyclic RGD-containing macrocycles are prepared using aziridine aldehydes, isocyanides, and linear peptides, followed by conjugation to a cysteamine linker. Our method involves site-selective aziridine ring-opening with the
Lovell JF, Jin CS, Huynh E, MacDonald TD, Cao W & Zheng G Angewandte Chemie International Edition, 2012 A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although