Corbin IR, Ng KK, Ding L, Jurisicova A, Zheng G Nanomedicine, 2013 DOI: 10.2217/nnm.12.137 Aim: The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer. Materials & methods: Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targetingContinue Reading

Jin CS, Lovell JF & Zheng G Journal of Visualized Experiments, 2013 We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy inContinue Reading

Huynh E & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013 Multifunctional nanoparticles have been developed to overcome the conventional hurdles associated with the diagnosis and treatment of disease. However, there are often caveats involved with the development and clinical translation of multifunctional nanoparticles largely regarding the notion thatContinue Reading

Jin CS, Lovell JF, Chen J & Zheng G ACS Nano, 2013 Tumor hypoxia is increasingly being recognized as a characteristic feature of solid tumors and significantly complicates many treatments based on radio-, chemo-, and phototherapies. While photodynamic therapy (PDT) is based on photosensitizer interactions with diffused oxygen, photothermal therapyContinue Reading