Roxin A, Chen J, Paton AS, Bender TP & Zheng G Journal of Medicinal Chemistry, 2013 With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening ofContinue Reading
Corbin IR, Ng KK, Ding L, Jurisicova A, Zheng G Nanomedicine, 2013 DOI: 10.2217/nnm.12.137 Aim: The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer. Materials & methods: Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targetingContinue Reading
Liu TW, Stewart JM, Macdonald TD, Chen J, Clarke B, Shi J, Wilson BC, Neel B & Zheng G Theranostics, 2013 Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum.Continue Reading
Jin CS, Lovell JF & Zheng G Journal of Visualized Experiments, 2013 We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy inContinue Reading
Lin Q, Chen J, Ng KK, Cao W, Zhang Z & Zheng G Pharmaceutical Research, 2013 Purpose: Molecular therapeutics often require an effective nanoparticle-based delivery strategy to transport them to cytosolic organelles to be functional. Recently, a cytosolic delivery strategy based on the scavenger receptor class B type I (SR-BI)Continue Reading
Liu TW, Macdonald TD, Jin CS, Gold JM, Bristow RG, Wilson BC & Zheng G ACS Nano, 2013 Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: (1)Continue Reading
Ng KK, Lovell JF, Vedadi A, Hajian T & Zheng G ACS Nano, 2013 The abilities to deliver and subsequently activate a therapeutic at the intended site of action are two important challenges in the synthesis of novel nanoparticles. Poor tumor permeability as a result of a dense microenvironment canContinue Reading
Huynh E & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013 Multifunctional nanoparticles have been developed to overcome the conventional hurdles associated with the diagnosis and treatment of disease. However, there are often caveats involved with the development and clinical translation of multifunctional nanoparticles largely regarding the notion thatContinue Reading
Jin CS, Lovell JF, Chen J & Zheng G ACS Nano, 2013 Tumor hypoxia is increasingly being recognized as a characteristic feature of solid tumors and significantly complicates many treatments based on radio-, chemo-, and phototherapies. While photodynamic therapy (PDT) is based on photosensitizer interactions with diffused oxygen, photothermal therapyContinue Reading
