Huang H, Cruz W, Chen J & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2014 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs delivery over
Roxin Á, MacDonald TD, Zheng G Journal of Porphyrins and Phthalocyanines, 2014 DOI: 10.1142/S1088424613501058 Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is
Lin Q, Chen J, Zhang Z, Zheng G Nanomedicine, 2014 DOI: 10.2217/nnm.13.192 RNAi therapeutics are believed to be the future of personalized medicine and have shown promise in early clinical trials. However, many physiological barriers exist in the systemic delivery of siRNAs to the cytoplasm of targeted cells to perform
Roxin A, Chen J, Paton AS, Bender TP, Zheng G Journal of Medicinal Chemistry, 2014 DOI: 10.1021/jm401538h With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening of bacteriochlorophyll derivatives and
MacDonald TD, Zheng G Photonics & Lasers in Medicine, 2014 DOI: 10.1515/plm-2013-0059 Porphysomes are an emerging class of photonic nanoparticles formed from the self-assembly of porphyrin-lipid conjugates. They retain the multifunctional properties of their porphyrin building blocks but also have unique properties emerging from the nanostructure itself. Porphysomes are able to act
Ng KK, Shakiba M, Huynh E, Weersink R, Roxin A, Wilson BC & Zheng G ACS Nano, 2014 Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal.
MacDonald TD, Liu TW & Zheng G Angewandte Chemie International Edition, 2014 Photothermal therapy makes use of photothermal sensitizers and laser light to thermally ablate diseased tissues. Porphysome nanoparticles offer a nontoxic alternative to inorganic nanocrystals for the efficient conversion of light into heat. Mn3+ ions were incorporated directly into
Lin Q, Jin CS, Huang H, Ding L & Zheng G Small, 2014 The abilities to deliver siRNA to its intended action site and assess the delivery efficiency are challenges for current RNAi therapy, where effective siRNA delivery will join force with patient genetic profiling to achieve optimal treatment outcome.
Huynh E & Zheng G NanoToday, 2014 The traditional role of lipids in the generation of lipid-based supramolecular structures has predominantly been to serve as building blocks to support the delivery or stabilization of a molecule or structure. With an introduction to the synthesis of porphyrin-lipid, a porphyrin conjugated to
Huynh E, Jin CS, Wilson BC & Zheng G Bioconjugate Chemistry, 2014 Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate of