2017

Pellow C, Goertz DE & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017 DOI: 10.1002/wnan.1502 The development of encapsulated microbubbles (~1–6 μm) has expanded the utility of ultrasound from soft tissue anatomical imaging to not only functional intravascular imaging, but therapeutic interventions, with compelling studies of elicited biological effects. TheContinue Reading

Rajora MA, Lou JWH & Zheng G Chemical Society Reviews, 2017 DOI: 10.1039/C7CS00525C Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity.Continue Reading

Overchuk M & Zheng G Biomaterials, 2017 DOI: 10.1016/j.biomaterials.2017.10.024 Despite rapid advancements in the field of nanotechnology, there is mounting frustration in the scientific community regarding the translational impact of nanomedicine. Modest therapeutic performance of FDA-approved nanomedicines combined with multiple disappointing clinical trials (such as phase III HEAT trial) haveContinue Reading

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G, Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular imagingContinue Reading

Zhang CJ, Valic MS, Chen J, Zheng G STEM Fellowship Journal, 2017 DOI: 10.17975/sfj-2017-007 Porphysome nanoparticles are composed of porphyrin-conjugated lipids. The attachment of the porphyrin moiety to each phospholipid confers novel properties to the liposome-like nanoparticle, allowing it to perform a variety of diagnostic and therapeutic applications. The metalContinue Reading

Luby BM & Zheng G Angewandte Chemie, 2017 DOI: 10.1002/anie.201707366 MicroRNA detection is a valuable method for determining cell identity. Molecular beacons are elegant sensors that can transform intracellular microRNA concentration into a fluorescence intensity. While target binding enhances beacon fluorescence, the degree of enhancement is insufficient for demanding applications.Continue Reading

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G & Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. MolecularContinue Reading