Pellow C, Goertz DE & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017 DOI: 10.1002/wnan.1502 The development of encapsulated microbubbles (~1–6 μm) has expanded the utility of ultrasound from soft tissue anatomical imaging to not only functional intravascular imaging, but therapeutic interventions, with compelling studies of elicited biological effects. The
Rajora MA, Lou JWH & Zheng G Chemical Society Reviews, 2017 DOI: 10.1039/C7CS00525C Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity.
Overchuk M & Zheng G Biomaterials, 2017 DOI: 10.1016/j.biomaterials.2017.10.024 Despite rapid advancements in the field of nanotechnology, there is mounting frustration in the scientific community regarding the translational impact of nanomedicine. Modest therapeutic performance of FDA-approved nanomedicines combined with multiple disappointing clinical trials (such as phase III HEAT trial) have
Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G, Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular imaging
Zhang CJ, Valic MS, Chen J, Zheng G STEM Fellowship Journal, 2017 DOI: 10.17975/sfj-2017-007 Porphysome nanoparticles are composed of porphyrin-conjugated lipids. The attachment of the porphyrin moiety to each phospholipid confers novel properties to the liposome-like nanoparticle, allowing it to perform a variety of diagnostic and therapeutic applications. The metal
Luby BM & Zheng G Angewandte Chemie, 2017 DOI: 10.1002/anie.201707366 MicroRNA detection is a valuable method for determining cell identity. Molecular beacons are elegant sensors that can transform intracellular microRNA concentration into a fluorescence intensity. While target binding enhances beacon fluorescence, the degree of enhancement is insufficient for demanding applications.
Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G & Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular
Rajora MA, Ding L, Valic M, Jiang W, Overchuk M, Chen J & Zheng G Chemical Science, 2017 DOI: 10.1039/C7SC00732A The development of curative glioblastoma treatments and tumour-specific contrast agents that can overcome the blood–brain barrier (BBB) and infiltrative tumour morphology remains a challenge. Apolipoprotein E3 (apoE3) is a high