Muhanna N, Chan H, Townson JL, Jin CS, Ding L, Valic M, Douglas CM, MacLaughlin CM, Chen J, Zheng G, Irish JC Endocrine-related cancer, 2019 DOI: 10.1530/ERC-19-0258 The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancerContinue Reading
Overchuk M, Damen MPF, Harmatys KM, Pomper MG, Chen J & Zheng GPhotochemistry and Photobiology, 2019DOI:10.1111/php.13181 Targeted photodynamic therapy (PDT) combined with image‐guided surgical resection is a promising strategy for precision cancer treatment. Prostate‐specific membrane antigen (PSMA) is an attractive target due to its pronounced overexpression in a variety ofContinue Reading
Guidolin K & Zheng GACS Nano, 2019DOI:10.1021/acsnano.9b08659 Nanomedicines have historically struggled to find clinical relevance and to achieve translation successfully. In this Perspective, we discuss possible reasons for this difficulty and highlight several key features of nanomedicines that are often overlooked by biomedical engineers. We present the notion of clinicalContinue Reading
Philp L, Chan H, Rouzbahman M, Rostami A, Ding L, Bratman SV, Akens MK, Irish JC, Bernardini MO & Zheng GJournal of Visualized Experiments, 2019DOI:0.3791/59340 Endometrial cancer is the most common gynecologic malignancy in North America and the incidence is rising worldwide. Treatment consists of surgery with or without adjuvantContinue Reading
Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading
Philp L, Chan H, Rouzbahman M, Rostami A, Ding L, Bratman SV, Akens MK, Irish JC, Bernardini MQ, Zheng G JoVE (Journal of Visualized Experiments), 2019 DOI: 10.3791/59340 Endometrial cancer is the most common gynecologic malignancy in North America and the incidence is rising worldwide. Treatment consists of surgery withContinue Reading
Dhaliwal A, Zheng G Theranostics, 2019 DOI:10.7150/thno.37204 The enhanced permeability and retention (EPR) effect has underlain the predominant nanomedicine design philosophy for the past three decades. However, growing evidence suggests that it is over-represented in preclinical models, and agents designed solely using its principle of passive accumulation can only beContinue Reading
Hou W, Lou J, Bu J, Chang E, Ding L Valic M, Jeon HH, Charron DM, Coolens C, Cui D, Chen J & Zheng G Angewandte Chemie, 2019 DOI: 10.1002/anie.201908664 A nanoemulsion with a porphyrin shell (NewPS) is created by the self‐assembly of porphyrin salt around an oil core. TheContinue Reading
Cheng MHY, Harmatys KM, Charron DM, Chen J & Zheng G Angewandte Chemie, 2019 DOI: 10.1002/ange.201907754 Organic building blocks are the centerpieces of “one‐for‐all” nanoparticle development, wherein their self‐assembly into a nanostructure can induce novel nanoscale properties and advance design of nanoparticles for cancer imaging. Herein, we report the synthesisContinue Reading
Cheng MHY, Bao S, Zheng G & Chen J Journal of Porphyrins and Phthalocyanines, 2019 DOI: 10.1142/S108842461950041X A pH-driven self-assembly of a simple aza-BODIPY was discovered in PBS solution, whereby ion-specific J-aggregated nanostructures were generated at very low dye concentration (2.5–20 μM). The aggregation process was investigated in different conditionsContinue Reading
