Overchuk M, Damen MPF, Harmatys KM, Pomper MG, Chen J & Zheng GPhotochemistry and Photobiology, 2019DOI:10.1111/php.13181 Targeted photodynamic therapy (PDT) combined with image‐guided surgical resection is a promising strategy for precision cancer treatment. Prostate‐specific membrane antigen (PSMA) is an attractive target due to its pronounced overexpression in a variety ofContinue Reading

Guidolin K & Zheng GACS Nano, 2019DOI:10.1021/acsnano.9b08659 Nanomedicines have historically struggled to find clinical relevance and to achieve translation successfully. In this Perspective, we discuss possible reasons for this difficulty and highlight several key features of nanomedicines that are often overlooked by biomedical engineers. We present the notion of clinicalContinue Reading

Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading

Dhaliwal A, Zheng G Theranostics, 2019 DOI:10.7150/thno.37204 The enhanced permeability and retention (EPR) effect has underlain the predominant nanomedicine design philosophy for the past three decades. However, growing evidence suggests that it is over-represented in preclinical models, and agents designed solely using its principle of passive accumulation can only beContinue Reading

Cheng MHY, Bao S, Zheng G & Chen J Journal of Porphyrins and Phthalocyanines, 2019 DOI: 10.1142/S108842461950041X A pH-driven self-assembly of a simple aza-BODIPY was discovered in PBS solution, whereby ion-specific J-aggregated nanostructures were generated at very low dye concentration (2.5–20 μM). The aggregation process was investigated in different conditionsContinue Reading