Cruz W, Huang H, Barber B, Pasini E, Ding L, Zheng G, Chen J, Bhat M Hepatology Communications, 2020 DOI: 10.1002/hep4.1493 Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffoldContinue Reading

Pellow C, Tan J, Chérin E, Demore CME, Zheng G, Goertz DE Ultrasonics, 2020 DOI: 10.1016/j.ultras.2020.106245 Emerging contrast imaging studies have highlighted the potential of nanobubbles for both intravascular and extravascular applications. Reports to date on nanobubbles have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL−1), and B-mode or contrast-modeContinue Reading

Pellow C, O’Reilly MA, Hynynen K, Zheng G & Goertz DENano Letters, 2020DOI:10.1021/acs.nanolett.0c01310 Ultrasound-activated nanobubbles are being widely investigated as contrast agents and therapeutic vehicles. Nanobubbles hold potential for accessing the tumor extravascular compartment, though this relies on clinically debated passive accumulation for which evidence to date is indirect. WeContinue Reading

Charron DM, Yousefalizadeh G, Buzza HH, Rajora MA, Chen J, Stamplecoskie KG, Zheng GLangmuirDOI:10.1021/acs.langmuir.0c00843 Porphyrin aggregates have attractive photophysical properties for phototherapy and optical imaging, including quenched photosensitization, efficient photothermal conversion, and unique absorption spectra. Although hydrophobic porphyrin photosensitizers have long been encapsulated into liposomes for drug delivery, little isContinue Reading

Valic MS, Hamlin M, Schimmer P & Zheng GJournal of Controlled ReleaseDOI:10.1016/j.jconrel.2020.04.002 A shared feature in the value proposition of every nanomaterial-based drug delivery systems is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of the encapsulated drug being delivered. Remarkable progress has been made towards understandingContinue Reading

Choi V, Rajora MA & Zheng GBioconjugate Chemistry, 2020DOI:10.1021/acs.bioconjchem.0c00029 Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadlyContinue Reading