Kassab G, Doran K, Mo Y, Zheng G Nano Letters DOI: 10.1021/acs.nanolett.3c03547 Lung-targeting RNA-carrying lipid nanoparticles (LNPs) are often intravenously administered and accumulate in the pulmonary endothelium. However, most respiratory diseases are localized in the airway or the alveolar epithelium. Inhalation has been explored as a more direct delivery method,Continue Reading
Kwon N, Jasinevicius GO, Kassab G, Ding L, Bu J, Martinelli LP, Ferreira VG, Dhaliwal A, Chan HHL, Mo Y, Bagnato VS, Kurachi C, Chen J, Zheng G Angewandte Chemie DOI: 10.1002/anie.202305564 Indocyanine green (ICG) is the only NIR-dye approved for clinical use. Despite its versatility in photonic applications andContinue Reading
Walsh C, Rajora MA, Ding L, Nakamura S, Endisha H, Rockel J, Chen J, Kapoor M, Zheng G Chemical Biomedical Imaging DOI: 10.1021/cbmi.3c00005 Despite the substantial burden posed by osteoarthritis (OA) globally, difficult challenges remain in achieving early OA diagnosis and adopting effective disease-modifying treatments. In this study, we useContinue Reading
Mo Y, Cheng MHY, D’Elia A, Doran K, Ding L, Chen J, Cullis PR, Zheng G ACS Nano DOI: 10.1021/acsnano.2c10936 Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the cytosol remains a fundamental challenge forContinue Reading
Ho T, Guidolin K, Makky A, Valic M, Ding L, Bu J, Zheng M, Cheng MHY, Yau J, Chen J, Zheng G Angewandte Chemie DOI: 10.1002/anie.202218218 Nanoparticles’ uptake by cancer cells upon reaching the tumor microenvironment is often the rate-limiting step in cancer nanomedicine. Herein, we report that the inclusionContinue Reading
Guidolin K, Ding L, Chen J, Zheng G Advanced Therapeutics DOI: 10.1002/adtp.202200342 Photodynamic therapy (PDT) is an anticancer treatment modality that has been poorly adopted into clinical practice for a variety of factors. Though fundamental studies supporting its utility abound, few clinical trials have been performed on its use. ThisContinue Reading
Lou J, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responsesContinue Reading
