Mo Y, Cheng MHY, D’Elia A, Doran K, Ding L, Chen J, Cullis PR, Zheng G ACS Nano DOI: 10.1021/acsnano.2c10936 Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the cytosol remains a fundamental challenge forContinue Reading
Ho T, Guidolin K, Makky A, Valic M, Ding L, Bu J, Zheng M, Cheng MHY, Yau J, Chen J, Zheng G Angewandte Chemie DOI: 10.1002/anie.202218218 Nanoparticles’ uptake by cancer cells upon reaching the tumor microenvironment is often the rate-limiting step in cancer nanomedicine. Herein, we report that the inclusionContinue Reading
Lou J, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responsesContinue Reading
Buzza HH, Alves F, Tome AJB, Chen J, Kassab G, Bu J, Bagnato VS, Zheng G, Kurachi C PNAS DOI: 10.1073/pnas.2216239119 The management of biofilm-related infections is a challenge in healthcare, and antimicrobial photodynamic therapy (aPDT) is a powerful tool that has demonstrated a broad-spectrum activity. Nanotechnology has been usedContinue Reading
Guidolin K, Ding L, Yan H, Englesakis M, Chadi S, Quereshy F, Zheng G Surgical Innovation DOI: 10.1177/15533506221083545 Photodynamic therapy (PDT) is a therapeutic modality that can be used to ablate tumors using the localized generation of reactive oxygen species by combining a photosensitizer, light, and molecular oxygen. This modalityContinue Reading
