Pellow C, Abenojar EC, Exner AA, Zheng G, Goertz DE Theranostics, 2020 DOI: 10.7150/thno.51316 Background: There has been growing interest in nanobubbles for their potential to extend bubble-mediated ultrasound approaches beyond that of their larger microbubble counterparts. In particular, the smaller scale of nanobubbles may enable them to access the tumorContinue Reading
Pellow C, Tan J, Chérin E, Demore CME, Zheng G, Goertz DE Ultrasonics, 2020 DOI: 10.1016/j.ultras.2020.106245 Emerging contrast imaging studies have highlighted the potential of nanobubbles for both intravascular and extravascular applications. Reports to date on nanobubbles have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL−1), and B-mode or contrast-modeContinue Reading
Pellow C, O’Reilly MA, Hynynen K, Zheng G & Goertz DENano Letters, 2020DOI:10.1021/acs.nanolett.0c01310 Ultrasound-activated nanobubbles are being widely investigated as contrast agents and therapeutic vehicles. Nanobubbles hold potential for accessing the tumor extravascular compartment, though this relies on clinically debated passive accumulation for which evidence to date is indirect. WeContinue Reading
Pellow C, Acconcia CN, Zheng G & Goertz DE Physics in Medicine and Biology, 2018 DOI: 10.1088/1361-6560/aae571 Nanobubbles hold potential for expanding utility of ultrasound contrast-based applications to extravascular targets, but their acoustic response and the effects of the surrounding environment remain relatively unexplored. Here we investigate the dynamics ofContinue Reading
Huynh E, Leung BYC, Helfield BL, Shakiba M, Gandier J, Jin CS, Master ER, Wilson BC, Goertz DE & Zheng G Nature Nanotechnology, 2015 (Download author version here) Converting nanoparticles or monomeric compounds into larger supramolecular structures by endogenous or external stimuli is increasingly popular because these materials are usefulContinue Reading
Huynh E, Jin CS, Wilson BC & Zheng G Bioconjugate Chemistry, 2014 Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate ofContinue Reading
Huynh E, Lovell JF, Helfield BL, Jeon M, Kim C, Goertz DE, Wilson BC, & Zheng G Journal of the American Chemical Society, 2012 Porphyrin–phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell (“porshe”), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin–lipidContinue Reading
