Lin Q, Jin CS, Huang H, Ding L & Zheng G Small, 2014 The abilities to deliver siRNA to its intended action site and assess the delivery efficiency are challenges for current RNAi therapy, where effective siRNA delivery will join force with patient genetic profiling to achieve optimal treatment outcome.Continue Reading
Huynh E & Zheng G NanoToday, 2014 The traditional role of lipids in the generation of lipid-based supramolecular structures has predominantly been to serve as building blocks to support the delivery or stabilization of a molecule or structure. With an introduction to the synthesis of porphyrin-lipid, a porphyrin conjugated toContinue Reading
Huynh E, Jin CS, Wilson BC & Zheng G Bioconjugate Chemistry, 2014 Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate ofContinue Reading
Huynh E, Lovell JF, Fobel R & Zheng G Small, 2014 Efforts to develop self-contained microreactors and artificial cells have been limited by difficulty in generating membranes that can be robustly and repeatedly manipulated to load and release cargo from phospholipid compartments. Here we describe a purely optical method toContinue Reading
Roxin A, Chen J, Paton AS, Bender TP & Zheng G Journal of Medicinal Chemistry, 2013 With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening ofContinue Reading
Huynh E & Zheng G IEEE Journal of Selected Topics in Quantum Electronics, 2014 Biophotonic nanoparticles have been of increasing interest for their ability to both image and treat disease. The majority of biophotonic nanoparticles developed have been inorganic in nature. Only recently has there been an increase in theContinue Reading
Corbin IR, Ng KK, Ding L, Jurisicova A, Zheng G Nanomedicine, 2013 DOI: 10.2217/nnm.12.137 Aim: The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer. Materials & methods: Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targetingContinue Reading
Liu TW, Stewart JM, Macdonald TD, Chen J, Clarke B, Shi J, Wilson BC, Neel B & Zheng G Theranostics, 2013 Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum.Continue Reading
Jin CS, Lovell JF & Zheng G Journal of Visualized Experiments, 2013 We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy inContinue Reading
Lin Q, Chen J, Ng KK, Cao W, Zhang Z & Zheng G Pharmaceutical Research, 2013 Purpose: Molecular therapeutics often require an effective nanoparticle-based delivery strategy to transport them to cytosolic organelles to be functional. Recently, a cytosolic delivery strategy based on the scavenger receptor class B type I (SR-BI)Continue Reading
