Liu TW, Macdonald TD, Jin CS, Gold JM, Bristow RG, Wilson BC & Zheng G ACS Nano, 2013 Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: (1)Continue Reading
Ng KK, Lovell JF, Vedadi A, Hajian T & Zheng G ACS Nano, 2013 The abilities to deliver and subsequently activate a therapeutic at the intended site of action are two important challenges in the synthesis of novel nanoparticles. Poor tumor permeability as a result of a dense microenvironment canContinue Reading
Huynh E & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013 Multifunctional nanoparticles have been developed to overcome the conventional hurdles associated with the diagnosis and treatment of disease. However, there are often caveats involved with the development and clinical translation of multifunctional nanoparticles largely regarding the notion thatContinue Reading
Jin CS, Lovell JF, Chen J & Zheng G ACS Nano, 2013 Tumor hypoxia is increasingly being recognized as a characteristic feature of solid tumors and significantly complicates many treatments based on radio-, chemo-, and phototherapies. While photodynamic therapy (PDT) is based on photosensitizer interactions with diffused oxygen, photothermal therapyContinue Reading
Lin Q, Chen J, Jin H, Ng KK, Yang M, Cao W, Ding L, Zhang Z & Zheng G Nanomedicine, 2012 The main challenge for RNAi therapeutics lies in systemic delivery of siRNA to the correct tissues and transporting them into the cytoplasm of targeted cells, at safe, therapeutic levels.Continue Reading
Liu TW, MacDonald TD, Shi J, Wilson BC & Zheng G Angewandte Chemie International Edition, 2012 PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one-pot, high-yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activityContinue Reading
Jin H, Chen J, Lovell JF, Zhang Z, Zheng G Israel Journal of Chemistry, 2012 DOI: 10.1002/ijch.201100054 The design and synthesis of new light‐activated contrast agents for theranostics (therapy/diagnosis) has the potential to facilitate multifunctional and improved personalized medicine. The use of light as a remote activation strategy provides spatialContinue Reading
Tam N, McVeigh P, MacDonald TD, Farhadi A, Wilson BC & Zheng G Bioconjugate Chemistry, 2012 A porphyrin–phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocalContinue Reading
Roxin A & Zheng G Future Medicinal Chemistry, 2012 Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long-standing focus within peptide research is the creation of structurally constrained peptides generated through cyclization. Cyclization isContinue Reading
Huynh E, Lovell JF, Helfield BL, Jeon M, Kim C, Goertz DE, Wilson BC, & Zheng G Journal of the American Chemical Society, 2012 Porphyrin–phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell (“porshe”), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin–lipidContinue Reading
