ZhengLab (Page 4)

Charron DM, Yousefalizadeh G, Buzza HH, Rajora MA, Chen J, Stamplecoskie KG, Zheng GLangmuirDOI:10.1021/acs.langmuir.0c00843 Porphyrin aggregates have attractive photophysical properties for phototherapy and optical imaging, including quenched photosensitization, efficient photothermal conversion, and unique absorption spectra. Although hydrophobic porphyrin photosensitizers have long been encapsulated into liposomes for drug delivery, little isContinue Reading

Valic MS, Hamlin M, Schimmer P & Zheng GJournal of Controlled ReleaseDOI:10.1016/j.jconrel.2020.04.002 A shared feature in the value proposition of every nanomaterial-based drug delivery systems is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of the encapsulated drug being delivered. Remarkable progress has been made towards understandingContinue Reading

Overchuk M, Damen MPF, Harmatys KM, Pomper MG, Chen J & Zheng GPhotochemistry and Photobiology, 2019DOI:10.1111/php.13181 Targeted photodynamic therapy (PDT) combined with image‐guided surgical resection is a promising strategy for precision cancer treatment. Prostate‐specific membrane antigen (PSMA) is an attractive target due to its pronounced overexpression in a variety ofContinue Reading

Choi V, Rajora MA & Zheng GBioconjugate Chemistry, 2020DOI:10.1021/acs.bioconjchem.0c00029 Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadlyContinue Reading

Guidolin K & Zheng GACS Nano, 2019DOI:10.1021/acsnano.9b08659 Nanomedicines have historically struggled to find clinical relevance and to achieve translation successfully. In this Perspective, we discuss possible reasons for this difficulty and highlight several key features of nanomedicines that are often overlooked by biomedical engineers. We present the notion of clinicalContinue Reading

Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading

Dhaliwal A, Zheng G Theranostics, 2019 DOI:10.7150/thno.37204 The enhanced permeability and retention (EPR) effect has underlain the predominant nanomedicine design philosophy for the past three decades. However, growing evidence suggests that it is over-represented in preclinical models, and agents designed solely using its principle of passive accumulation can only beContinue Reading