Publications (Page 15)

Stefflova K, Chen J & Zheng G Current Medicinal Chemistry, 2007 Precisely localizing therapeutic agents in neoplastic areas would greatly improve their efficacy for killing tumor cells and reduce their toxicity to normal cells. Photodynamic therapy (PDT) is a promising cancer treatment modality, and near-infrared fluorescence imaging (NIRF-I) is aContinue Reading

Stefflova K, Chen J Li H & Zheng G Molecular Imaging, 2006 Imaging apoptotic cells or tissues after cancer therapy in situ would be a very useful tool for assessing proper treatment conditions and therapeutic outcome. By combining therapeutic and imaging functions, we have designed a multifunctional, membrane-permeable, and cancer-specificContinue Reading

Zheng G, Chen J, Li H & Glickson, JD Proceedings of the National Academy of Sciences, 2005 We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated receptors. Multiple copiesContinue Reading

Li H, Marotta DE, Kim S, Busch TM, Wileyto EP & Zheng G Journal of Biomedical Optics, 2005 To improve the labeling efficiency of a low-density lipoprotein (LDL)-based photosensitizer (PS) for achieving high probe to protein payload, a tetra-tt-butyl silicon phthalocyanine bearing two oleate moieties at its axial positions, SiPcBOA,Continue Reading

Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD & Therien MJ Bioconjugate Chemistry, 2005 Meso-to-meso ethyne-bridged tris[(porphinato)zinc(II)] (PZn3) near-infrared (NIR) fluorophores (λemmax ∼800 nm) can be rendered sufficiently amphiphilic to enable their facile incorporation into the hydrophobic core of the apo form of low-density lipoprotein (apo-LDL).Continue Reading