Pellow C, Chérin E, Abenojar EC, Exner AA, Zheng G, Démoré CEM, Goertz D IEEE, 2021 DOI: 10.1109/TUFFC.2021.3055141 There has been growing interest in nanobubbles for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL-1), andContinue Reading
Overchuk M, Harmatys KM, Sindhwani S, Rajora MA, Koebel A, Charron DM, Syed AM, Chen J, Pomper MG, Wilson BC, Chan WCW, Zheng G Nano Letters, 2020 DOI: 10.1021/acs.nanolett.0c03731 Limited tumor nanoparticle accumulation remains one of the main challenges in cancer nanomedicine. Here, we demonstrate that subtherapeutic photodynamic priming (PDP)Continue Reading
Cheng MHY, Mo Y, Zheng G Advanced Healthcare Materials, 2020 DOI: 10.1002/adhm.202001549 Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis and resistance development. Conventional hypoxia detection methods lack continuous functional detection and are generally less suitable for dynamic hypoxia measurement. Optical sensorsContinue Reading
Muhanna N, Chan H, Townson JL, Jin CS, Ding L, Valic M, Douglas CM, MacLaughlin CM, Chen J, Zheng G, Irish JC Endocrine-related cancer, 2019 DOI: 10.1530/ERC-19-0258 The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancerContinue Reading
Cruz W, Huang H, Barber B, Pasini E, Ding L, Zheng G, Chen J, Bhat M Hepatology Communications, 2020 DOI: 10.1002/hep4.1493 Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffoldContinue Reading
Pellow C, Abenojar EC, Exner AA, Zheng G, Goertz DE Theranostics, 2020 DOI: 10.7150/thno.51316 Background: There has been growing interest in nanobubbles for their potential to extend bubble-mediated ultrasound approaches beyond that of their larger microbubble counterparts. In particular, the smaller scale of nanobubbles may enable them to access the tumorContinue Reading
Pellow C, Tan J, Chérin E, Demore CME, Zheng G, Goertz DE Ultrasonics, 2020 DOI: 10.1016/j.ultras.2020.106245 Emerging contrast imaging studies have highlighted the potential of nanobubbles for both intravascular and extravascular applications. Reports to date on nanobubbles have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL−1), and B-mode or contrast-modeContinue Reading
Pellow C, O’Reilly MA, Hynynen K, Zheng G & Goertz DENano Letters, 2020DOI:10.1021/acs.nanolett.0c01310 Ultrasound-activated nanobubbles are being widely investigated as contrast agents and therapeutic vehicles. Nanobubbles hold potential for accessing the tumor extravascular compartment, though this relies on clinically debated passive accumulation for which evidence to date is indirect. WeContinue Reading
Charron DM, Yousefalizadeh G, Buzza HH, Rajora MA, Chen J, Stamplecoskie KG, Zheng GLangmuirDOI:10.1021/acs.langmuir.0c00843 Porphyrin aggregates have attractive photophysical properties for phototherapy and optical imaging, including quenched photosensitization, efficient photothermal conversion, and unique absorption spectra. Although hydrophobic porphyrin photosensitizers have long been encapsulated into liposomes for drug delivery, little isContinue Reading
Valic MS, Hamlin M, Schimmer P & Zheng GJournal of Controlled ReleaseDOI:10.1016/j.jconrel.2020.04.002 A shared feature in the value proposition of every nanomaterial-based drug delivery systems is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of the encapsulated drug being delivered. Remarkable progress has been made towards understandingContinue Reading
