Publications (Page 3)

Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy

Chang E, Bu J, Ding L, Lou JWH, Valic MS, Cheng MHY, Rosilio V, Chen J, Zheng G Journal of Nanobiotechnology DOI: 10.1186/s12951-021-00898-1 Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porphyrin nanodroplet (liquefied gas-core),Continue Reading

Fast, facile, base-free microwave-assisted metallation of bacteriochlorophylls and corresponding high yield synthesis of TOOKAD

Cheng MHY, Cevallos A, Rajora MA, Zheng G Journal of Porphyrins and Pthalocyanines, 2021 DOI: 10.1142/S1088424621500656 Naturally-derived metallo-bacteriochlorophylls have attracted much attention since their clinical approval for cancer photodynamic therapy. Their therapeutic properties are rooted in the metal complexation of bacteriochlorophylls, which endows them with optical properties favourable for biophotonicContinue Reading

High Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo

Pellow C, Chérin E, Abenojar EC, Exner AA, Zheng G, Démoré CEM, Goertz D IEEE, 2021 DOI: 10.1109/TUFFC.2021.3055141 There has been growing interest in nanobubbles for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL-1), andContinue Reading

Subtherapeutic Photodynamic Treatment Facilitates Tumor Nanomedicine Delivery and Overcomes Desmoplasia

Overchuk M, Harmatys KM, Sindhwani S, Rajora MA, Koebel A, Charron DM, Syed AM, Chen J, Pomper MG, Wilson BC, Chan WCW, Zheng G Nano Letters, 2020 DOI: 10.1021/acs.nanolett.0c03731 Limited tumor nanoparticle accumulation remains one of the main challenges in cancer nanomedicine. Here, we demonstrate that subtherapeutic photodynamic priming (PDP)Continue Reading

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Cheng MHY, Mo Y, Zheng G Advanced Healthcare Materials, 2020 DOI: 10.1002/adhm.202001549 Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis and resistance development. Conventional hypoxia detection methods lack continuous functional detection and are generally less suitable for dynamic hypoxia measurement. Optical sensorsContinue Reading

Photodynamic therapy enables tumor-specific ablation in preclinical models of thyroid cancer

Muhanna N, Chan H, Townson JL, Jin CS, Ding L, Valic M, Douglas CM, MacLaughlin CM, Chen J, Zheng G, Irish JC Endocrine-related cancer, 2019 DOI: 10.1530/ERC-19-0258 The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancerContinue Reading

Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden

Cruz W, Huang H, Barber B, Pasini E, Ding L, Zheng G, Chen J, Bhat M Hepatology Communications, 2020 DOI: 10.1002/hep4.1493 Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffoldContinue Reading

Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors

Pellow C, Abenojar EC, Exner AA, Zheng G, Goertz DE Theranostics, 2020 DOI: 10.7150/thno.51316 Background: There has been growing interest in nanobubbles for their potential to extend bubble-mediated ultrasound approaches beyond that of their larger microbubble counterparts. In particular, the smaller scale of nanobubbles may enable them to access the tumorContinue Reading

High frequency ultrasound nonlinear scattering from porphyrin nanobubbles

Pellow C, Tan J, Chérin E, Demore CME, Zheng G, Goertz DE Ultrasonics, 2020 DOI: 10.1016/j.ultras.2020.106245 Emerging contrast imaging studies have highlighted the potential of nanobubbles for both intravascular and extravascular applications. Reports to date on nanobubbles have generally utilized low frequencies (<12 MHz), high concentrations (>109 mL−1), and B-mode or contrast-modeContinue Reading

Simultaneous intravital optical and acoustic monitoring of ultrasound-triggered nanobubble generation and extravasation

Pellow C, O’Reilly MA, Hynynen K, Zheng G & Goertz DENano Letters, 2020DOI:10.1021/acs.nanolett.0c01310 Ultrasound-activated nanobubbles are being widely investigated as contrast agents and therapeutic vehicles. Nanobubbles hold potential for accessing the tumor extravascular compartment, though this relies on clinically debated passive accumulation for which evidence to date is indirect. WeContinue Reading