Huynh E, Rajora MA & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2016 Ultrasound (US) is one of the most commonly used clinical imaging techniques. However, the use of US and US-based intravenous agents extends far beyond imaging. In particular, there has been a surge in the fabrication ofContinue Reading
Charron DM, Chen J & Zheng G ChemNanoMat, 2016 Nanocarriers incorporating therapeutic and imaging agents within a single nanostructure are emerging tools for drug development and treatment planning. Additional information can be provided using activatable fluorescence that dynamically reports nanocarrier disruption and drug release. Dual-wavelength activation encodes a unique fluorescenceContinue Reading
Liu TW, Akens MK, Chen J, Wilson BC & Zheng G Photochemical and Photobiological Sciences, 2016 The metastatic spread of cancer from the primary site or organ is one of its most devastating aspects, being responsible for up to 90% of cancer-associated mortality. Bone is one of the common sitesContinue Reading
Shakiba M, Ng KK, Huynh E, Chan H, Charron DM, Chen J, Muhanna N, Foster FS, Wilson BC & Zheng G Nanoscale, 2016 J-aggregates display nanoscale optical properties which enable their use in fluorescence and photoacoustic imaging applications. However, control over their optical properties in an in vivo setting isContinue Reading
Cui L, Tokarz D, Cisek R, Ng KK, Wang F, Chen J, Barzda V & Zheng G Angewandte Chemie International Edition, 2015 Nonlinear optical microscopy has become a powerful tool for high-resolution imaging of cellular and subcellular composition, morphology, and interactions because of its high spatial resolution, deep penetration, andContinue Reading
Muhanna N, Cui L, Chan H, Burgess L, Jin CS, MacDonald TD, Huynh E, Wang F, Chen J, Irish JC & Zheng G Clinical Cancer Research, 2015 Purpose: The low survival rate of head-and-neck cancer (HNC) patients is attributable to late disease diagnosis and high recurrence rate. Current HNC stagingContinue Reading
Farhadi A, Roxin Á, Wilson BC, Zheng G Theranostics, 2015 DOI: 10.7150/thno.10694 To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has inContinue Reading
Huang H, Cruz W, Chen J, Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015 DOI: 10.1002/wnan.1308 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs deliveryContinue Reading
Muhanna N, Jin CS, Huynh E, Chan H, Qiu Y, Jiang W, Cui L, Burgess L, Akens MK, Chen J, Irish JC Theranostics, 2015 DOI: 10.7150/thno.13451 Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity toContinue Reading
Muhanna N, MacDonald TD, Chan H, Jin CS, Burgess L, Cui L, Chen J, Irish JC & Zheng G Advanced Healthcare Materials, 2015 DOI: 10.1002/ange.201803535 64Cu-porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emissionContinue Reading
