MacDonald TD, Zheng G Photonics & Lasers in Medicine, 2014 DOI: 10.1515/plm-2013-0059 Porphysomes are an emerging class of photonic nanoparticles formed from the self-assembly of porphyrin-lipid conjugates. They retain the multifunctional properties of their porphyrin building blocks but also have unique properties emerging from the nanostructure itself. Porphysomes are able to actContinue Reading
Ng KK, Shakiba M, Huynh E, Weersink R, Roxin A, Wilson BC & Zheng G ACS Nano, 2014 Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal.Continue Reading
MacDonald TD, Liu TW & Zheng G Angewandte Chemie International Edition, 2014 Photothermal therapy makes use of photothermal sensitizers and laser light to thermally ablate diseased tissues. Porphysome nanoparticles offer a nontoxic alternative to inorganic nanocrystals for the efficient conversion of light into heat. Mn3+ ions were incorporated directly intoContinue Reading
Lin Q, Jin CS, Huang H, Ding L & Zheng G Small, 2014 The abilities to deliver siRNA to its intended action site and assess the delivery efficiency are challenges for current RNAi therapy, where effective siRNA delivery will join force with patient genetic profiling to achieve optimal treatment outcome.Continue Reading
Huynh E & Zheng G NanoToday, 2014 The traditional role of lipids in the generation of lipid-based supramolecular structures has predominantly been to serve as building blocks to support the delivery or stabilization of a molecule or structure. With an introduction to the synthesis of porphyrin-lipid, a porphyrin conjugated toContinue Reading
Huynh E, Jin CS, Wilson BC & Zheng G Bioconjugate Chemistry, 2014 Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate ofContinue Reading
Huynh E, Lovell JF, Fobel R & Zheng G Small, 2014 Efforts to develop self-contained microreactors and artificial cells have been limited by difficulty in generating membranes that can be robustly and repeatedly manipulated to load and release cargo from phospholipid compartments. Here we describe a purely optical method toContinue Reading
Roxin A, Chen J, Paton AS, Bender TP & Zheng G Journal of Medicinal Chemistry, 2013 With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening ofContinue Reading
Huynh E & Zheng G IEEE Journal of Selected Topics in Quantum Electronics, 2014 Biophotonic nanoparticles have been of increasing interest for their ability to both image and treat disease. The majority of biophotonic nanoparticles developed have been inorganic in nature. Only recently has there been an increase in theContinue Reading
Corbin IR, Ng KK, Ding L, Jurisicova A, Zheng G Nanomedicine, 2013 DOI: 10.2217/nnm.12.137 Aim: The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer. Materials & methods: Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targetingContinue Reading
