Tam NC, Scott BMT, Voicu D, Wilson BC & Zheng G Bioconjugate Chemistry, 2010 Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates RamanContinue Reading

Hill ML, Corbin IR, Levitin RB, Cao W, Mainprize JG, Yaffe MJ & Zheng G Academic Radiology, 2010 Rationale and Objectives: Targeted molecular probes offer the potential for greater specificity in cancer imaging with contrast-enhanced computed tomography (CT). We investigate a low-density lipoprotein (LDL) nanoparticle loaded with poly-iodinated triglyceride (ITG)Continue Reading

Lovell JF, Jin H, Ng KK & Zheng G Angewandte Chemie International Edition, 2010 Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon resultsContinue Reading

Lovell JF, Chen J, Huynh E, Jarvi MT, Wilson BC & Zheng G Bioconjugate Chemistry, 2010 Nucleic acid photodynamic molecular beacons (PMBs) are a class of activatable photosensitizers that increase singlet oxygen generation upon binding a specific target sequence. Normally, PMBs are functionalized with multiple solution-phase labeling and purification steps.Continue Reading

Liu TWB, Chen J & Zheng G Amino Acids, 2010 Peptide-based molecular beacons are Förster resonance energy transfer-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets and thus are useful tools for in vivo cancer imaging. With our increasing knowledge about human genome inContinue Reading

Lovell JF, Liu TWB, Chen J & Zheng G Chemical Reviews, 2010 Photodynamic therapy (PDT) is a minimally invasive treatment that destroys target cells in the presence of oxygen when light irradiates a photosensitizer, generating highly reactive singlet oxygen. PDT has low systemic toxicity, it can emission of fluorescence. PhotosensitizersContinue Reading