Rajora MA & Zheng G Frontiers in Pharmacology, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancerContinue Reading
Luby BM, Charron DM, MacLaughlin CM & Zheng G Advanced Drug Delivery Reviews, 2016 Molecular imaging has emerged as an indispensable technology in the development and application of drug delivery systems. Targeted imaging agents report the presence of biomolecules, including therapeutic targets and disease biomarkers, while the biological behaviour ofContinue Reading
MacLaughlin CM, Ding L, Jin C, Cao P, Siddiqui I, Hwang DM, Chen J, Wilson BC, Zheng G & Hedley DW Journal of Biomedical Optics, 2016 Local disease control is a major challenge in pancreatic cancer treatment, because surgical resection of the primary tumor is only possible in a minorityContinue Reading
Ng KK, Weersink RA, Lim L, Wilson BC & Zheng G Angewandte Chemie International Edition, 2016 Photothermal therapy (PTT) is enhanced by the use of nanoparticles with a large optical absorption at the treatment wavelength. However, this comes at the cost of higher light attenuation that results in reduced depthContinue Reading
Jin CS, Overchuk M, Cui L, Wilson BC, Bristow RG, Chen J & Zheng G The Prostate, 2016 BACKGROUND The Magnetic Resonance Imaging (MRI)-guided focal laser therapy has shown early promise in Phase 1 trial treating low/intermediate-risk localized prostate cancer (PCa), but the lack of tumor selectivity and low efficiencyContinue Reading
Keca JM, Chen J, Overchuk M, Muhanna N, MacLaughlin CM, Jin CS, Foltz WD, Irish JC & Zheng G Angewandte Chemie International Edition, 2016 The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable and multifunctional chelators. However, they remain elusive asContinue Reading
Ng KK, Takada M, Harmatys K, Chen J & Zheng G ACS Nano, 2016 Chlorosomes are vesicular light-harvesting organelles found in photosynthetic green sulfur bacteria. These organisms thrive in low photon flux environments due to the most efficient light-to-chemical energy conversion, promoted by a protein-less assembly of chlorin pigments. TheseContinue Reading
Huynh E, Rajora MA & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2016 Ultrasound (US) is one of the most commonly used clinical imaging techniques. However, the use of US and US-based intravenous agents extends far beyond imaging. In particular, there has been a surge in the fabrication ofContinue Reading
Charron DM, Chen J & Zheng G ChemNanoMat, 2016 Nanocarriers incorporating therapeutic and imaging agents within a single nanostructure are emerging tools for drug development and treatment planning. Additional information can be provided using activatable fluorescence that dynamically reports nanocarrier disruption and drug release. Dual-wavelength activation encodes a unique fluorescenceContinue Reading
Burgess L, Chen J, Wolter NE, Wilson BC & Zheng G Biomedical Optics Express, 2016 Each year almost 300,000 individuals worldwide are diagnosed with oral cancer, more than 90% of these being oral carcinoma [N. Engl. J. Med. 328, 184 1993]. Surgical resection is the standard of care, but accurateContinue Reading
