Cheng M, Overchuk M, Rajora MA, Lou JWH, Chen W, Pomper MG, Chen J, Zheng G ACS Molecular Pharmaceutics DOI: 10.1021/acs.molpharmaceut.1c00819 Theranostic nanoparticles aim to integrate diagnostic imaging and therapy to facilitate image-guided treatment protocols. Herein, we present a theranostic nanotexaphyrin for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and focalContinue Reading

Yoo K, Dhaliwal A, Chen J, Sheeran PS, Zheng G JoVE (Journal of Visualized Experiments) DOI: 10.3791/62665 Phase-change droplets are a class of ultrasound contrast agents that can convert into echogenic microbubbles in situ with the application of sufficient acoustic energy. Droplets are smaller and more stable than their microbubble counterparts. However,Continue Reading

Guidolin K, Ding L, Chen J, Wilson BC, Zheng G Nanophotonics DOI: 10.1515/nanoph-2021-0220 Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focusedContinue Reading

Chang E, Bu J, Ding L, Lou JWH, Valic MS, Cheng MHY, Rosilio V, Chen J, Zheng G Journal of Nanobiotechnology DOI: 10.1186/s12951-021-00898-1 Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porphyrin nanodroplet (liquefied gas-core),Continue Reading

Cheng MHY, Cevallos A, Rajora MA, Zheng G Journal of Porphyrins and Pthalocyanines, 2021 DOI: 10.1142/S1088424621500656 Naturally-derived metallo-bacteriochlorophylls have attracted much attention since their clinical approval for cancer photodynamic therapy. Their therapeutic properties are rooted in the metal complexation of bacteriochlorophylls, which endows them with optical properties favourable for biophotonicContinue Reading