Prolonged Circulating Lipid Nanoparticles Enabled by High-Density Gd-DTPA-Bis(stearylamide) for Long-Lasting Enhanced Tumor Magnetic Resonance Imaging
2022-10-28
Margalik DA, Chen J, Ho T, Ding L, Dhaliwal A, Doria AS, Zheng G Bioconjugate Chemistry DOI: 10.1021/acs.bioconjchem.2c00445 Porphysomes (PS) were explored to incorporate different types of diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids into their bilayer membrane to assess PS potential as an MRI contrast agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide)Continue Reading