Walsh C, Rajora MA, Ding L, Nakamura S, Endisha H, Rockel J, Chen J, Kapoor M, Zheng G Chemical Biomedical Imaging DOI: 10.1021/cbmi.3c00005 Despite the substantial burden posed by osteoarthritis (OA) globally, difficult challenges remain in achieving early OA diagnosis and adopting effective disease-modifying treatments. In this study, we useContinue Reading
Mo Y, Cheng MHY, D’Elia A, Doran K, Ding L, Chen J, Cullis PR, Zheng G ACS Nano DOI: 10.1021/acsnano.2c10936 Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the cytosol remains a fundamental challenge forContinue Reading
Ho T, Guidolin K, Makky A, Valic M, Ding L, Bu J, Zheng M, Cheng MHY, Yau J, Chen J, Zheng G Angewandte Chemie DOI: 10.1002/anie.202218218 Nanoparticles’ uptake by cancer cells upon reaching the tumor microenvironment is often the rate-limiting step in cancer nanomedicine. Herein, we report that the inclusionContinue Reading
Guidolin K, Ding L, Chen J, Zheng G Advanced Therapeutics DOI: 10.1002/adtp.202200342 Photodynamic therapy (PDT) is an anticancer treatment modality that has been poorly adopted into clinical practice for a variety of factors. Though fundamental studies supporting its utility abound, few clinical trials have been performed on its use. ThisContinue Reading
Lou J, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responsesContinue Reading
Cressey P, Abuillan W, Ibrahim N, Alhoussein J, Konovalov O, Zheng G, Makky A ChemPhysChem DOI: 10.1002/cphc.202200687 Lipid-porphyrin conjugates are versatile compounds which can self-assemble into liposome-like structures with multifunctional properties. Most of the conjugates that have been described so far, consisted in grafting pyropheophorbide-a (Pyro-a) or other porphyrin derivativesContinue Reading
Lou JW, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 * To promote more open access to science, the Zheng lab has paidContinue Reading
Buzza HH, Alves F, Tome AJB, Chen J, Kassab G, Bu J, Bagnato VS, Zheng G, Kurachi C PNAS DOI: 10.1073/pnas.2216239119 The management of biofilm-related infections is a challenge in healthcare, and antimicrobial photodynamic therapy (aPDT) is a powerful tool that has demonstrated a broad-spectrum activity. Nanotechnology has been usedContinue Reading
Guidolin K, Ding L, Yan H, Englesakis M, Chadi S, Quereshy F, Zheng G Surgical Innovation DOI: 10.1177/15533506221083545 Photodynamic therapy (PDT) is a therapeutic modality that can be used to ablate tumors using the localized generation of reactive oxygen species by combining a photosensitizer, light, and molecular oxygen. This modalityContinue Reading
Husby T, Valic M, Zheng G, Wilson BC, Weersink R SPIE BiOS DOI: 10.1117/12.2609870 We present ongoing work to develop and verify a measurement technology using diffuse reflectance spectroscopy and fluorescence spectroscopy to measure in-vivo concentrations of intact and dissociated porphysomes. Porphysomes (PS) are multifunctional liposome-like nanoparticles composed of porphyrin-lipidContinue Reading
