Porph

Guidolin K, Ding L, Chen J, Wilson BC, Zheng G Nanophotonics DOI: 10.1515/nanoph-2021-0220 Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focusedContinue Reading

Chang E, Bu J, Ding L, Lou JWH, Valic MS, Cheng MHY, Rosilio V, Chen J, Zheng G Journal of Nanobiotechnology DOI: 10.1186/s12951-021-00898-1 Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porphyrin nanodroplet (liquefied gas-core),Continue Reading

Charron DM, Yousefalizadeh G, Buzza HH, Rajora MA, Chen J, Stamplecoskie KG, Zheng GLangmuirDOI:10.1021/acs.langmuir.0c00843 Porphyrin aggregates have attractive photophysical properties for phototherapy and optical imaging, including quenched photosensitization, efficient photothermal conversion, and unique absorption spectra. Although hydrophobic porphyrin photosensitizers have long been encapsulated into liposomes for drug delivery, little isContinue Reading

Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading

Philp L, Chan H, Rouzbahman M, Overchuk M, Chen J, Zheng G & Bernardini MQ Theranostics, 2019 DOI: 10.7150/thno.31225 Objective: To investigate Porphysome fluorescence image-guided resection (PYRO-FGR) for detection of uterine tumour, metastatic lymph nodes and abdominal metastases in a model of endometrial cancer. Methods: White New Zealand rabbits wereContinue Reading

Keca JM, Valic MS, Cheng MHY, Jian W, Overchuk M, Chen J & Zheng G Advanced Healthcare Materials, 2018 DOI: 10.1002/adhm.201800857 The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all‐organic compounds that possess versatile metal‐chelation capabilities and unique theranostics propertiesContinue Reading

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G, Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular imagingContinue Reading

Zhang CJ, Valic MS, Chen J, Zheng G STEM Fellowship Journal, 2017 DOI: 10.17975/sfj-2017-007 Porphysome nanoparticles are composed of porphyrin-conjugated lipids. The attachment of the porphyrin moiety to each phospholipid confers novel properties to the liposome-like nanoparticle, allowing it to perform a variety of diagnostic and therapeutic applications. The metalContinue Reading