Porph

Radiopharmaceutical kit to prepare Copper-64 labelled porphyrin-lipid nanoparticles for radiotracer imaging studies in cancer patients

Radiopharmaceutical kit to prepare Copper-64 labelled porphyrin-lipid nanoparticles for radiotracer imaging studies in cancer patients Valic MS, Fisher CJ, Zheng M, Gregor AM, Jiang W, Chan C, Chan HHL, et al. European Journal of Nuclear Medicine and Molecular Imaging, 2025 DOI: 10.1007/s00259-025-07012-3 Abstract Porphyrin-lipid nanoparticles (porphysomes) are intrinsically multimodal nanoparticlesContinue Reading

Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects

Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects Nankivell VA, Sandeman L, Stretton L, Vidanapathirana AK, Rajora MA, et al. Materials Today Bio, 2025 DOI: 10.1016/j.mtbio.2025.102202 Abstract Atherosclerosis remains the leading cause of cardiovascular morbidity and mortality worldwide, and non-invasive methods for early plaque detection andContinue Reading

Porphyrin-based nanotechnology: a minimally invasive approach for drug delivery and cholesteatoma treatment

Porphyrin-based nanotechnology: a minimally invasive approach for drug delivery and cholesteatoma treatment Mahmoud DA, Ding L, Ferdous Z, Zhang Z, Chen J, Spiegel JL, Sykes EA, et al. Frontiers in Surgery, 2025 DOI:Continue Reading

A membrane fluidization strategy significantly boosts photodynamic therapy and antitumor immunity of porphyrin-lipid nanoparticles

A membrane fluidization strategy significantly boosts photodynamic therapy and antitumor immunity of porphyrin-lipid nanoparticles Ho T, Valic M, Liu TW, Zheng M, Yang Y, Guidolin K, Ding L, Mo Y, Qian A, et al. ACS Nano Medicine, 2025 DOI: 10.1021/acsnanomed.5c00053 Abstract PhotodynamicContinue Reading

Cutaneous photosensitivity of phototheranostic porphyrin–lipid nanoparticles

Cutaneous photosensitivity of phototheranostic porphyrin–lipid nanoparticles Valic MS, Zheng M, Husby T, Guidolin K, Sahovaler A, Tzelnick S, et al. Photochemistry and Photobiology, 2025 DOI: 10.1111/php.13996 AbstractContinue Reading

Protease-Activatable Porphyrin Molecular Beacon for Osteoarthritis Management

Walsh C, Rajora MA, Ding L, Nakamura S, Endisha H, Rockel J, Chen J, Kapoor M, Zheng G Chemical Biomedical Imaging DOI: 10.1021/cbmi.3c00005 Despite the substantial burden posed by osteoarthritis (OA) globally, difficult challenges remain in achieving early OA diagnosis and adopting effective disease-modifying treatments. In this study, we useContinue Reading

Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles

Mo Y, Cheng MHY, D’Elia A, Doran K, Ding L, Chen J, Cullis PR, Zheng G ACS Nano DOI: 10.1021/acsnano.2c10936 Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the cytosol remains a fundamental challenge forContinue Reading

Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy

Ho T, Guidolin K, Makky A, Valic M, Ding L, Bu J, Zheng M, Cheng MHY, Yau J, Chen J, Zheng G Angewandte Chemie DOI: 10.1002/anie.202218218 Nanoparticles’ uptake by cancer cells upon reaching the tumor microenvironment is often the rate-limiting step in cancer nanomedicine. Herein, we report that the inclusionContinue Reading

Development of a Clinically Viable Strategy for Nanoparticle-Based Photodynamic Therapy of Colorectal Cancer

Guidolin K, Ding L, Chen J, Zheng G Advanced Therapeutics DOI: 10.1002/adtp.202200342 Photodynamic therapy (PDT) is an anticancer treatment modality that has been poorly adopted into clinical practice for a variety of factors. Though fundamental studies supporting its utility abound, few clinical trials have been performed on its use. ThisContinue Reading

Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy

Lou J, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responsesContinue Reading