Overchuk M, Harmatys KM, Sindhwani S, Rajora MA, Koebel A, Charron DM, Syed AM, Chen J, Pomper MG, Wilson BC, Chan WCW, Zheng G Nano Letters, 2020 DOI: 10.1021/acs.nanolett.0c03731 Limited tumor nanoparticle accumulation remains one of the main challenges in cancer nanomedicine. Here, we demonstrate that subtherapeutic photodynamic priming (PDP)Continue Reading
Farhadi A, Roxin Á, Wilson BC, Zheng G Theranostics, 2015 DOI: 10.7150/thno.10694 To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has inContinue Reading
Roxin Á, MacDonald TD, Zheng G Journal of Porphyrins and Phthalocyanines, 2014 DOI: 10.1142/S1088424613501058 Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and isContinue Reading
Roxin A, Chen J, Paton AS, Bender TP, Zheng G Journal of Medicinal Chemistry, 2014 DOI: 10.1021/jm401538h With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening of bacteriochlorophyll derivatives andContinue Reading
Liu TW, Stewart JM, Macdonald TD, Chen J, Clarke B, Shi J, Wilson BC, Neel B & Zheng G Theranostics, 2013 Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum.Continue Reading
Roxin A, Chen J, Scully CC, Rotstein BH, Yudin AK & Zheng G Bioconjugate Chemistry, 2012 Here, we demonstrate a conjugation strategy whereby cyclic RGD-containing macrocycles are prepared using aziridine aldehydes, isocyanides, and linear peptides, followed by conjugation to a cysteamine linker. Our method involves site-selective aziridine ring-opening with theContinue Reading
Shi J, Liu TW, Chen J, Green D, Jaffray D, Wilson BC, Wang F & Zheng G Theranostics, 2011 Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles forContinue Reading
Liu TW, Chen J, Burgess L, Cao W, Shi J, Wilson BC & Zheng G Theranostics, 2011 The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a meansContinue Reading
Stefflova K, Li H, Chen J & Zheng G Bioconjugate Chemistry, 2007 We designed and synthesized a folate receptor-targeted, water-soluble, and pharmacomodulated photodynamic therapy (PDT) agent that selectively detects and destroys the targeted cancer cells while sparing normal tissue. This was achieved by minimizing the normal organ uptake (e.g., liverContinue Reading
Zhang Z, Li H, Liu Q, Zhou L, Zhang M, Luo Q, Glickson J, Chance B & Zheng G Biosensors and Bioelectronics, 2004 One of the biochemical “hallmarks” of malignancy is enhanced tumor glycolysis, which is primary due to the overexpression of glucose transporters (GLUTs) and the increased activity ofContinue Reading
