PS

Yoo K, Dhaliwal A, Chen J, Sheeran PS, Zheng G JoVE (Journal of Visualized Experiments) DOI: 10.3791/62665 Phase-change droplets are a class of ultrasound contrast agents that can convert into echogenic microbubbles in situ with the application of sufficient acoustic energy. Droplets are smaller and more stable than their microbubble counterparts. However,Continue Reading

Guidolin K, Ding L, Chen J, Wilson BC, Zheng G Nanophotonics DOI: 10.1515/nanoph-2021-0220 Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focusedContinue Reading

Cheng MHY, Cevallos A, Rajora MA, Zheng G Journal of Porphyrins and Pthalocyanines, 2021 DOI: 10.1142/S1088424621500656 Naturally-derived metallo-bacteriochlorophylls have attracted much attention since their clinical approval for cancer photodynamic therapy. Their therapeutic properties are rooted in the metal complexation of bacteriochlorophylls, which endows them with optical properties favourable for biophotonicContinue Reading

Farhadi A, Roxin Á, Wilson BC, Zheng G Theranostics, 2015 DOI: 10.7150/thno.10694 To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has inContinue Reading

Roxin Á, MacDonald TD, Zheng G Journal of Porphyrins and Phthalocyanines, 2014 DOI: 10.1142/S1088424613501058 Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and isContinue Reading

Roxin A, Chen J, Paton AS, Bender TP, Zheng G Journal of Medicinal Chemistry, 2014 DOI: 10.1021/jm401538h With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening of bacteriochlorophyll derivatives andContinue Reading

Roxin A, Chen J, Scully CC, Rotstein BH, Yudin AK & Zheng G Bioconjugate Chemistry, 2012 Here, we demonstrate a conjugation strategy whereby cyclic RGD-containing macrocycles are prepared using aziridine aldehydes, isocyanides, and linear peptides, followed by conjugation to a cysteamine linker. Our method involves site-selective aziridine ring-opening with theContinue Reading