PS

Farhadi A, Roxin Á, Wilson BC, Zheng G Theranostics, 2015 DOI: 10.7150/thno.10694 To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has inContinue Reading

Roxin Á, MacDonald TD, Zheng G Journal of Porphyrins and Phthalocyanines, 2014 DOI: 10.1142/S1088424613501058 Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and isContinue Reading

Roxin A, Chen J, Paton AS, Bender TP, Zheng G Journal of Medicinal Chemistry, 2014 DOI: 10.1021/jm401538h With the knowledge that the dominant photodynamic therapy (PDT) mechanism of 1a (WST09) switched from type 2 to type 1 for 1b (WST11) upon taurine-driven E-ring opening, we hypothesized that taurine-driven E-ring opening of bacteriochlorophyll derivatives andContinue Reading

Roxin A, Chen J, Scully CC, Rotstein BH, Yudin AK & Zheng G Bioconjugate Chemistry, 2012 Here, we demonstrate a conjugation strategy whereby cyclic RGD-containing macrocycles are prepared using aziridine aldehydes, isocyanides, and linear peptides, followed by conjugation to a cysteamine linker. Our method involves site-selective aziridine ring-opening with theContinue Reading

Liu TW, Chen J, Burgess L, Cao W, Shi J, Wilson BC & Zheng G Theranostics, 2011 The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a meansContinue Reading