Guidolin K, Ding L, Chen J, Zheng G Advanced Therapeutics DOI: 10.1002/adtp.202200342 Photodynamic therapy (PDT) is an anticancer treatment modality that has been poorly adopted into clinical practice for a variety of factors. Though fundamental studies supporting its utility abound, few clinical trials have been performed on its use. ThisContinue Reading
Lou JW, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 * To promote more open access to science, the Zheng lab has paidContinue Reading
Buzza HH, Alves F, Tome AJB, Chen J, Kassab G, Bu J, Bagnato VS, Zheng G, Kurachi C PNAS DOI: 10.1073/pnas.2216239119 The management of biofilm-related infections is a challenge in healthcare, and antimicrobial photodynamic therapy (aPDT) is a powerful tool that has demonstrated a broad-spectrum activity. Nanotechnology has been usedContinue Reading
Margalik DA, Chen J, Ho T, Ding L, Dhaliwal A, Doria AS, Zheng G Bioconjugate Chemistry DOI: 10.1021/acs.bioconjchem.2c00445 Porphysomes (PS) were explored to incorporate different types of diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids into their bilayer membrane to assess PS potential as an MRI contrast agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide)Continue Reading
Husby T, Valic M, Zheng G, Wilson BC, Weersink R SPIE BiOS DOI: 10.1117/12.2609870 We present ongoing work to develop and verify a measurement technology using diffuse reflectance spectroscopy and fluorescence spectroscopy to measure in-vivo concentrations of intact and dissociated porphysomes. Porphysomes (PS) are multifunctional liposome-like nanoparticles composed of porphyrin-lipidContinue Reading
Cheng M, Overchuk M, Rajora MA, Lou JWH, Chen W, Pomper MG, Chen J, Zheng G ACS Molecular Pharmaceutics DOI: 10.1021/acs.molpharmaceut.1c00819 Theranostic nanoparticles aim to integrate diagnostic imaging and therapy to facilitate image-guided treatment protocols. Herein, we present a theranostic nanotexaphyrin for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and focalContinue Reading
Yoo K, Dhaliwal A, Chen J, Sheeran PS, Zheng G JoVE (Journal of Visualized Experiments) DOI: 10.3791/62665 Phase-change droplets are a class of ultrasound contrast agents that can convert into echogenic microbubbles in situ with the application of sufficient acoustic energy. Droplets are smaller and more stable than their microbubble counterparts. However,Continue Reading
Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J, Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K Nanophotonics DOI: 10.1515/nanoph-2021-0220 While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptiveContinue Reading
Guidolin K, Ding L, Chen J, Wilson BC, Zheng G Nanophotonics DOI: 10.1515/nanoph-2021-0220 Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focusedContinue Reading
Cheng MHY, Cevallos A, Rajora MA, Zheng G Journal of Porphyrins and Pthalocyanines, 2021 DOI: 10.1142/S1088424621500656 Naturally-derived metallo-bacteriochlorophylls have attracted much attention since their clinical approval for cancer photodynamic therapy. Their therapeutic properties are rooted in the metal complexation of bacteriochlorophylls, which endows them with optical properties favourable for biophotonicContinue Reading
