Marotta DE, Cao W, Wileyto EP, Li H, Corbin I, Rickter E, Glickson JD, Chance B, Zheng G & Busch TM Nanomedicine, 2011 Aim: To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of humanContinue Reading
Lovell JF, Jin CS, Huynh E, Jin H, Kim C, Rubinstein JL, Chan WCW, Cao W, Wang LV & Zheng G Nature Materials, 2011 (Download author version here) Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeuticContinue Reading
Jin H, Lovell JF, Chen J, Ng KK, Ding L, Zhang Z & Zheng G Photochemical and Photobiological Sciences, 2011 Following cellular delivery, most drugs must escape endosomes and lysosomes and reach the cytosol to be effective. This is particularly significant for nanoparticles, which can carry a large drug payload,Continue Reading
Yang M, Jin H, Chen J, Ding L, Ng KK, Lin Q, Lovell JF, Zhang Z & Zheng G Small, 2011 High-density lipoprotein (HDL)-mimicking peptide–phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability ofContinue Reading
Shi J, Liu TW, Chen J, Green D, Jaffray D, Wilson BC, Wang F & Zheng G Theranostics, 2011 Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles forContinue Reading
Liu TW, Chen J, Burgess L, Cao W, Shi J, Wilson BC & Zheng G Theranostics, 2011 The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a meansContinue Reading
Jin H, Lovell JF, Chen J, Ng KK, Cao W, Ding L, Zhang Z & Zheng G Cancer Nanotechology, 2010 Targeted nanoparticles have the potential to deliver a large drug payload specifically to cancer cells. Targeting requires that a ligand on the nanoparticle surface interact with a specific membrane receptorContinue Reading
Tam NC, Scott BMT, Voicu D, Wilson BC & Zheng G Bioconjugate Chemistry, 2010 Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates RamanContinue Reading
Hill ML, Corbin IR, Levitin RB, Cao W, Mainprize JG, Yaffe MJ & Zheng G Academic Radiology, 2010 Rationale and Objectives: Targeted molecular probes offer the potential for greater specificity in cancer imaging with contrast-enhanced computed tomography (CT). We investigate a low-density lipoprotein (LDL) nanoparticle loaded with poly-iodinated triglyceride (ITG)Continue Reading
Lovell JF, Jin H, Ng KK & Zheng G Angewandte Chemie International Edition, 2010 Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon resultsContinue Reading
