Cheng MHY, Harmatys KM, Charron DM, Chen J & Zheng G Angewandte Chemie, 2019 DOI: 10.1002/ange.201907754 Organic building blocks are the centerpieces of “one‐for‐all” nanoparticle development, wherein their self‐assembly into a nanostructure can induce novel nanoscale properties and advance design of nanoparticles for cancer imaging. Herein, we report the synthesisContinue Reading
Cheng MHY, Bao S, Zheng G & Chen J Journal of Porphyrins and Phthalocyanines, 2019 DOI: 10.1142/S108842461950041X A pH-driven self-assembly of a simple aza-BODIPY was discovered in PBS solution, whereby ion-specific J-aggregated nanostructures were generated at very low dye concentration (2.5–20 μM). The aggregation process was investigated in different conditionsContinue Reading
Valic MS & Zheng G Theranostics, 2019 DOI: 10.7150/thno.34509 A critical step in the translational science of nanomaterials from preclinical animal studies to humans is the comprehensive investigation of their disposition (or ADME) and pharmacokinetic behaviours. Disposition and pharmacokinetic data are ideally collected in different animal species (rodent and nonrodent),Continue Reading
Harmatys KM, Overchuk M & Zheng G Accounts of Chemical Research, 2019 DOI: 10.1021/acs.accounts.9b00104 The sun is the most abundant source of energy on earth. Phototrophs have discovered clever strategies to harvest this light energy and convert it to chemical energy for biomass production. This is achieved in light-harvesting complexes,Continue Reading
Philp L, Chan H, Rouzbahman M, Overchuk M, Chen J, Zheng G & Bernardini MQ Theranostics, 2019 DOI: 10.7150/thno.31225 Objective: To investigate Porphysome fluorescence image-guided resection (PYRO-FGR) for detection of uterine tumour, metastatic lymph nodes and abdominal metastases in a model of endometrial cancer. Methods: White New Zealand rabbits wereContinue Reading
Overchuk M, Zheng M, Rajora MA, Charron DM, Chen J & Zheng G ACS Nano, 2019 DOI: 10.1021/acsnano.9b00494 Lipoprotein mimetic nanostructures, which consist of an amphiphilic lipid shell, a hydrophobic core, and an apolipoprotein mimetic peptide, serve as a versatile platform for the design of drug delivery vehicles as wellContinue Reading
Lou J, Zhang L & Zheng G Advanced Therapeutics, 2019 DOI: 10.1002/adtp.201800128 Cancer immunotherapies can elicit long term, durable responses in only a fraction of patients. As such, there is a need to increase the number of patients who can benefit from cancer immunotherapies. By virtue of their versatility andContinue Reading
Harmatys KM, Overchuk M, Chen J, Ding L, Chen Y, Pomper MG & Zheng G Bioconjugate Chemistry, 2018 DOI: 10.1021/acs.bioconjchem.8b00636 We describe a simple and effective bioconjugation strategy to extend the plasma circulation of a low molecular weight targeted phototheranostic agent, which achieves high tumor accumulation (9.74 ± 2.26 %ID/g)Continue Reading
Pellow C, Acconcia CN, Zheng G & Goertz DE Physics in Medicine and Biology, 2018 DOI: 10.1088/1361-6560/aae571 Nanobubbles hold potential for expanding utility of ultrasound contrast-based applications to extravascular targets, but their acoustic response and the effects of the surrounding environment remain relatively unexplored. Here we investigate the dynamics ofContinue Reading
Keca JM, Valic MS, Cheng MHY, Jian W, Overchuk M, Chen J & Zheng G Advanced Healthcare Materials, 2018 DOI: 10.1002/adhm.201800857 The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all‐organic compounds that possess versatile metal‐chelation capabilities and unique theranostics propertiesContinue Reading
