Shakiba M, Ng KK, Huynh E, Chan H, Charron DM, Chen J, Muhanna N, Foster FS, Wilson BC & Zheng G Nanoscale, 2016 J-aggregates display nanoscale optical properties which enable their use in fluorescence and photoacoustic imaging applications. However, control over their optical properties in an in vivo setting isContinue Reading
Cui L, Tokarz D, Cisek R, Ng KK, Wang F, Chen J, Barzda V & Zheng G Angewandte Chemie International Edition, 2015 Nonlinear optical microscopy has become a powerful tool for high-resolution imaging of cellular and subcellular composition, morphology, and interactions because of its high spatial resolution, deep penetration, andContinue Reading
Muhanna N, Cui L, Chan H, Burgess L, Jin CS, MacDonald TD, Huynh E, Wang F, Chen J, Irish JC & Zheng G Clinical Cancer Research, 2015 Purpose: The low survival rate of head-and-neck cancer (HNC) patients is attributable to late disease diagnosis and high recurrence rate. Current HNC stagingContinue Reading
Farhadi A, Roxin Á, Wilson BC, Zheng G Theranostics, 2015 DOI: 10.7150/thno.10694 To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has inContinue Reading
Huang H, Cruz W, Chen J, Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015 DOI: 10.1002/wnan.1308 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs deliveryContinue Reading
Muhanna N, Jin CS, Huynh E, Chan H, Qiu Y, Jiang W, Cui L, Burgess L, Akens MK, Chen J, Irish JC Theranostics, 2015 DOI: 10.7150/thno.13451 Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity toContinue Reading
Muhanna N, MacDonald TD, Chan H, Jin CS, Burgess L, Cui L, Chen J, Irish JC & Zheng G Advanced Healthcare Materials, 2015 DOI: 10.1002/ange.201803535 64Cu-porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emissionContinue Reading
Charron DM, Chen J & Zheng G Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer, 2015 Disease heterogeneity within and between patients necessitates a patient-focused approach to cancer treatment. This exigency forms the basis for the medical practice termed personalized medicine. An emerging, important component of personalized medicineContinue Reading
Ng KK & Zheng G Chemical Reviews, 2015 Optical and photonic technologies play an important role in human progress. The bending of light to our will has not only enabled our biological self-discovery, but has also allowed us to probe and investigate the natural life around us. These advancements haveContinue Reading
Cui L, Lin Q, Jin CS, Jiang W, Huang H, Ding L, Muhanna N, Irish JC, Wang F, Chen J & Zheng G ACS Nano, 2015 PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles’ vascular circulation by mitigating the reticuloendothelial system uptake. However, there remain many concernsContinue Reading
