Publications (Page 16)

High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles

Li H, Marotta DE, Kim S, Busch TM, Wileyto EP & Zheng G Journal of Biomedical Optics, 2005 To improve the labeling efficiency of a low-density lipoprotein (LDL)-based photosensitizer (PS) for achieving high probe to protein payload, a tetra-tt-butyl silicon phthalocyanine bearing two oleate moieties at its axial positions, SiPcBOA,Continue Reading

Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores

Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD & Therien MJ Bioconjugate Chemistry, 2005 Meso-to-meso ethyne-bridged tris[(porphinato)zinc(II)] (PZn3) near-infrared (NIR) fluorophores (λemmax ∼800 nm) can be rendered sufficiently amphiphilic to enable their facile incorporation into the hydrophobic core of the apo form of low-density lipoprotein (apo-LDL).Continue Reading

Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers

Zhang Z, Li H, Liu Q, Zhou L, Zhang M, Luo Q, Glickson J, Chance B & Zheng G Biosensors and Bioelectronics, 2004 One of the biochemical “hallmarks” of malignancy is enhanced tumor glycolysis, which is primary due to the overexpression of glucose transporters (GLUTs) and the increased activity ofContinue Reading

Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation

Chen J, Stefflova K, Niedre MJ, Wilson BC, Chance B, Glickson JD & Zheng G Journal of the American Chemical Society, 2004 We report a new concept for type-II photosensitization, based on incorporating the photosensitizer (PS) and a singlet-oxygen (1O2) quenching/scavenging molecule onto a disease-targeting linker, such that the PSContinue Reading

Redox ratio of mitochondria as an indicator for the response of photodynamic therapy

Zhang Z, Blessington D, Li H, Busch TM, Glickson J, Luo Q, Chance B & Zheng G Journal of Biomedical Optics, 2004 The effect of photodynamic therapy (PDT) treatment on the metabolic state of tumor mitochondria is investigated by imaging of tumor redox status. PDT is performed using the photosensitizerContinue Reading

Carbocyanine labeled LDL for optical imaging of tumors

Li H, Zhang Z, Blessington D, Nelson DS, Zhou R, Lund-Katz S, Chance B, Glickson JD & Zheng G Academic Radiology, 2004 Rationale and objectives: The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptorContinue Reading

Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies

Chen Y, Zheng G, Zhang ZH, Blessington D, Zhang M, Li H, Liu Q, Zhou L, Intes X, Achilefu S, Chance B Optics letters, 2003 DOI: 10.1364/OL.28.002070 We present a high-sensitivity near-infrared optical imaging system for noninvasive cancer detection and localization based on molecularly labeled fluorescent contrast agents. This frequency-domainContinue Reading

Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters

Zhang M, Zhang Z, Blessington D, Li H, Busch TM, Madrak V, Miles J, Chance B, Glickson JD, Zheng G Bioconjugate chemistry, 2003 DOI: 10.1021/bc034038n To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized and evaluated in a 9L glioma ratContinue Reading

Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia

Zheng G, Li H, Yang K, Blessington D, Licha K, Lund-Katz S, Chance B, Glickson JD Bioorganic & medicinal chemistry letters, 2002 DOI: 10.1016/s0960-894x(02)00193-2 For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moietyContinue Reading

Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer

Zheng G, Li H, Zhang M, Lund-Katz S, Chance B, Glickson JD Bioconjugate chemistry, 2002 DOI: 10.1021/bc025516h To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that thisContinue Reading