Publications (Page 5)

Research tools for extrapolating the disposition and pharmacokinetics of nanomaterials from preclinical animals to humans

Valic MS & Zheng G Theranostics, 2019 DOI: 10.7150/thno.34509 A critical step in the translational science of nanomaterials from preclinical animal studies to humans is the comprehensive investigation of their disposition (or ADME) and pharmacokinetic behaviours. Disposition and pharmacokinetic data are ideally collected in different animal species (rodent and nonrodent),Continue Reading

Rational design of photosynthesis-inspired nanomedicines

Harmatys KM, Overchuk M & Zheng G Accounts of Chemical Research, 2019 DOI: 10.1021/acs.accounts.9b00104 The sun is the most abundant source of energy on earth. Phototrophs have discovered clever strategies to harvest this light energy and convert it to chemical energy for biomass production. This is achieved in light-harvesting complexes,Continue Reading

Use of porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: Proof of concept in endometrial cancer

Philp L, Chan H, Rouzbahman M, Overchuk M, Chen J, Zheng G & Bernardini MQ Theranostics, 2019 DOI: 10.7150/thno.31225 Objective: To investigate Porphysome fluorescence image-guided resection (PYRO-FGR) for detection of uterine tumour, metastatic lymph nodes and abdominal metastases in a model of endometrial cancer. Methods: White New Zealand rabbits wereContinue Reading

Tailoring porphyrin conjugation for nanoassembly-driven phototheranostic properties

Overchuk M, Zheng M, Rajora MA, Charron DM, Chen J & Zheng G ACS Nano, 2019 DOI: 10.1021/acsnano.9b00494 Lipoprotein mimetic nanostructures, which consist of an amphiphilic lipid shell, a hydrophobic core, and an apolipoprotein mimetic peptide, serve as a versatile platform for the design of drug delivery vehicles as wellContinue Reading

Advancing cancer immunotherapies with nanotechnology

Lou J, Zhang L & Zheng G Advanced Therapeutics, 2019 DOI: 10.1002/adtp.201800128 Cancer immunotherapies can elicit long term, durable responses in only a fraction of patients. As such, there is a need to increase the number of patients who can benefit from cancer immunotherapies. By virtue of their versatility andContinue Reading

Tuning pharmacokinetics to improve tumor accumulation of a prostate-specific membrane antigen-targeted phototheranostic agent

Harmatys KM, Overchuk M, Chen J, Ding L, Chen Y, Pomper MG & Zheng G Bioconjugate Chemistry, 2018 DOI: 10.1021/acs.bioconjchem.8b00636 We describe a simple and effective bioconjugation strategy to extend the plasma circulation of a low molecular weight targeted phototheranostic agent, which achieves high tumor accumulation (9.74 ± 2.26 %ID/g)Continue Reading

Threshold-dependent nonlinear scattering from porphyrin nanobubbles for vascular and extravascular applications

Pellow C, Acconcia CN, Zheng G & Goertz DE Physics in Medicine and Biology, 2018 DOI: 10.1088/1361-6560/aae571 Nanobubbles hold potential for expanding utility of ultrasound contrast-based applications to extravascular targets, but their acoustic response and the effects of the surrounding environment remain relatively unexplored. Here we investigate the dynamics ofContinue Reading

Mixed and matched metallo-nanotexaphyrin for customizable biomedical imaging

Keca JM, Valic MS, Cheng MHY, Jian W, Overchuk M, Chen J & Zheng G Advanced Healthcare Materials, 2018 DOI: 10.1002/adhm.201800857 The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all‐organic compounds that possess versatile metal‐chelation capabilities and unique theranostics propertiesContinue Reading

Advanced photosensitizer activation strategies for smarter photodynamic therapy beacons

Luby BM, Walsh, CD & Zheng G Angewandte Chemie, 2018 DOI: 10.1002/ange.201805246 Photodynamic therapy (PDT) is a clinical treatment in which a light‐absorbing drug called a photosensitizer is combined with light and molecular oxygen to generate cytotoxic singlet oxygen. PDT provides additional tissue selectivity versus conventional chemotherapy in that singletContinue Reading

Multi‐pronged biomimetic approach to create optically tunable nanoparticles

Harmatys K, Chen J, Charron DM, MacLaughlin CM & Zheng G Angewandte Chemie, 2018 DOI: 10.1002/ange.201803535 Biomimetics are reconstructions of natural systems in engineered forms to exploit their structural or functional properties. Current biomimetics for medical applications use a single biomimetic approach to imitate natural structures, which can be insufficientContinue Reading