2022

Self-Organization of Lipid-Porphyrin Conjugates at the Air/Water Interface

Cressey P, Abuillan W, Ibrahim N, Alhoussein J, Konovalov O, Zheng G, Makky A ChemPhysChem DOI: 10.1002/cphc.202200687 Lipid-porphyrin conjugates are versatile compounds which can self-assemble into liposome-like structures with multifunctional properties. Most of the conjugates that have been described so far, consisted in grafting pyropheophorbide-a (Pyro-a) or other porphyrin derivativesContinue Reading

Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy

Lou JW, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 * To promote more open access to science, the Zheng lab has paidContinue Reading

Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections

Buzza HH, Alves F, Tome AJB, Chen J, Kassab G, Bu J, Bagnato VS, Zheng G, Kurachi C PNAS DOI: 10.1073/pnas.2216239119 The management of biofilm-related infections is a challenge in healthcare, and antimicrobial photodynamic therapy (aPDT) is a powerful tool that has demonstrated a broad-spectrum activity. Nanotechnology has been usedContinue Reading

Prolonged Circulating Lipid Nanoparticles Enabled by High-Density Gd-DTPA-Bis(stearylamide) for Long-Lasting Enhanced Tumor Magnetic Resonance Imaging

Margalik DA, Chen J, Ho T, Ding L, Dhaliwal A, Doria AS, Zheng G Bioconjugate Chemistry DOI: 10.1021/acs.bioconjchem.2c00445 Porphysomes (PS) were explored to incorporate different types of diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids into their bilayer membrane to assess PS potential as an MRI contrast agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide)Continue Reading

Photodynamic Therapy for Colorectal Cancer: A Systematic Review of Clinical Research

Guidolin K, Ding L, Yan H, Englesakis M, Chadi S, Quereshy F, Zheng G Surgical Innovation DOI: 10.1177/15533506221083545 Photodynamic therapy (PDT) is a therapeutic modality that can be used to ablate tumors using the localized generation of reactive oxygen species by combining a photosensitizer, light, and molecular oxygen. This modalityContinue Reading

Measurement of intact and dissociated porphyrin-lipid nanoparticle concentration in tissue using diffuse reflectance and fluorescence spectroscopy

Husby T, Valic M, Zheng G, Wilson BC, Weersink R SPIE BiOS DOI: 10.1117/12.2609870 We present ongoing work to develop and verify a measurement technology using diffuse reflectance spectroscopy and fluorescence spectroscopy to measure in-vivo concentrations of intact and dissociated porphysomes. Porphysomes (PS) are multifunctional liposome-like nanoparticles composed of porphyrin-lipidContinue Reading

Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment

Bakrania A, Zheng G, Bhat M Pharmaceutics DOI: 10.3390/pharmaceutics14010041 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and is associated with a dismal median survival of 2–9 months. The fundamental limitations and ineffectiveness of current HCC treatments have led to the development of a vast range ofContinue Reading