Lipo

Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy

Lou J, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responsesContinue Reading

Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy

Lou JW, Aragaki M, Bernards N, Chee T, Gregor A, Hiraishi Y, Ishiwata T, Leung C, Ding L, Kitazawa S, Koga T, Sata Y, Ogawa H, Chen J, Kato T, Yasufuku K, Zheng G Biomaterials DOI: 10.1016/j.biomaterials.2022.121918 * To promote more open access to science, the Zheng lab has paidContinue Reading

Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect

Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J, Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K Nanophotonics DOI: 10.1515/nanoph-2021-0220 While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptiveContinue Reading

Photodynamic therapy enables tumor-specific ablation in preclinical models of thyroid cancer

Muhanna N, Chan H, Townson JL, Jin CS, Ding L, Valic M, Douglas CM, MacLaughlin CM, Chen J, Zheng G, Irish JC Endocrine-related cancer, 2019 DOI: 10.1530/ERC-19-0258 The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancerContinue Reading

Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden

Cruz W, Huang H, Barber B, Pasini E, Ding L, Zheng G, Chen J, Bhat M Hepatology Communications, 2020 DOI: 10.1002/hep4.1493 Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffoldContinue Reading

Tailoring porphyrin conjugation for nanoassembly-driven phototheranostic properties

Overchuk M, Zheng M, Rajora MA, Charron DM, Chen J & Zheng G ACS Nano, 2019 DOI: 10.1021/acsnano.9b00494 Lipoprotein mimetic nanostructures, which consist of an amphiphilic lipid shell, a hydrophobic core, and an apolipoprotein mimetic peptide, serve as a versatile platform for the design of drug delivery vehicles as wellContinue Reading

Multi‐pronged biomimetic approach to create optically tunable nanoparticles

Harmatys K, Chen J, Charron DM, MacLaughlin CM & Zheng G Angewandte Chemie, 2018 DOI: 10.1002/ange.201803535 Biomimetics are reconstructions of natural systems in engineered forms to exploit their structural or functional properties. Current biomimetics for medical applications use a single biomimetic approach to imitate natural structures, which can be insufficientContinue Reading

Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma

Rajora MA, Ding L, Valic M, Jiang W, Overchuk M, Chen J & Zheng G Chemical Science, 2017 DOI: 10.1039/C7SC00732A The development of curative glioblastoma treatments and tumour-specific contrast agents that can overcome the blood–brain barrier (BBB) and infiltrative tumour morphology remains a challenge. Apolipoprotein E3 (apoE3) is a highContinue Reading

Nanostructure-dependent ratiometric NIR fluorescence enabled by ordered dye aggregation

Charron DM, Chen J & Zheng G ChemNanoMat, 2016 Nanocarriers incorporating therapeutic and imaging agents within a single nanostructure are emerging tools for drug development and treatment planning. Additional information can be provided using activatable fluorescence that dynamically reports nanocarrier disruption and drug release. Dual-wavelength activation encodes a unique fluorescenceContinue Reading

Multimodal image-guided surgical and photodynamic interventions in head-and-neck cancer: From primary tumor to metastatic drainage

Muhanna N, Cui L, Chan H, Burgess L, Jin CS, MacDonald TD, Huynh E, Wang F, Chen J, Irish JC & Zheng G Clinical Cancer Research, 2015 Purpose: The low survival rate of head-and-neck cancer (HNC) patients is attributable to late disease diagnosis and high recurrence rate. Current HNC stagingContinue Reading