Lipo (Page 4)

Zheng G, Chen J, Li H & Glickson, JD Proceedings of the National Academy of Sciences, 2005 We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated receptors. Multiple copiesContinue Reading

Li H, Marotta DE, Kim S, Busch TM, Wileyto EP & Zheng G Journal of Biomedical Optics, 2005 To improve the labeling efficiency of a low-density lipoprotein (LDL)-based photosensitizer (PS) for achieving high probe to protein payload, a tetra-tt-butyl silicon phthalocyanine bearing two oleate moieties at its axial positions, SiPcBOA,Continue Reading

Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD & Therien MJ Bioconjugate Chemistry, 2005 Meso-to-meso ethyne-bridged tris[(porphinato)zinc(II)] (PZn3) near-infrared (NIR) fluorophores (λemmax ∼800 nm) can be rendered sufficiently amphiphilic to enable their facile incorporation into the hydrophobic core of the apo form of low-density lipoprotein (apo-LDL).Continue Reading

Li H, Zhang Z, Blessington D, Nelson DS, Zhou R, Lund-Katz S, Chance B, Glickson JD & Zheng G Academic Radiology, 2004 Rationale and objectives: The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptorContinue Reading

Zheng G, Li H, Yang K, Blessington D, Licha K, Lund-Katz S, Chance B, Glickson JD Bioorganic & medicinal chemistry letters, 2002 DOI: 10.1016/s0960-894x(02)00193-2 For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moietyContinue Reading

Zheng G, Li H, Zhang M, Lund-Katz S, Chance B, Glickson JD Bioconjugate chemistry, 2002 DOI: 10.1021/bc025516h To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that thisContinue Reading