Song L, Li H, Sunar U, Chen J, Corbin I, Yodh AG, Zheng G International journal of nanomedicine, 2007 PMID: 18203443 Low density lipoproteins (LDLs) are naturally occurring nanoparticles that are biocompatible, biodegradable and non-immunogenic. Moreover, the size of LDL particle is precisely controlled (~22 nm) by its apoB-100 component,Continue Reading
Corbin IR, Chen J, Cao W, Li H, Lund-Katz S, Zheng G Journal of Biomedical Nanotechnology, 2007 DOI: 10.1166/jbn.2007.053 One of the greatest obstacles nanoscale drug delivery systems face is the high nonspecific uptake by the reticular endothelial system (RES). Currently, PEGylation is the method of choice to address thisContinue Reading
Chan J, Corbin IR, Li H, Cao W, Glickson JD & Zheng G Journal of the American Chemical Society, 2007 LDL particles are high-capacity nanocarriers with precisely controlled size and are naturally biocompatible, biodegradable, and nonimmunogenic. However, their utilities as drug carriers are limited by the narrow purview of LDLContinue Reading
Corbin IR, Li H, Chen J, Lund-Katz S, Zhou R, Glickson JD & Zheng G Neoplasia, 2006 Low-density lipoproteins (LDLs) are a naturally occurring endogenous nanoplatform in mammalian systems. These nanoparticles (22 nm) specifically transport cholesterol to cells expressing the LDL receptor (LDLR). Several tumors overexpress LDLRs presumably to provideContinue Reading
Zheng G, Chen J, Li H & Glickson, JD Proceedings of the National Academy of Sciences, 2005 We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated receptors. Multiple copiesContinue Reading
Li H, Marotta DE, Kim S, Busch TM, Wileyto EP & Zheng G Journal of Biomedical Optics, 2005 To improve the labeling efficiency of a low-density lipoprotein (LDL)-based photosensitizer (PS) for achieving high probe to protein payload, a tetra-tt-butyl silicon phthalocyanine bearing two oleate moieties at its axial positions, SiPcBOA,Continue Reading
Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD & Therien MJ Bioconjugate Chemistry, 2005 Meso-to-meso ethyne-bridged tris[(porphinato)zinc(II)] (PZn3) near-infrared (NIR) fluorophores (λemmax ∼800 nm) can be rendered sufficiently amphiphilic to enable their facile incorporation into the hydrophobic core of the apo form of low-density lipoprotein (apo-LDL).Continue Reading
Li H, Zhang Z, Blessington D, Nelson DS, Zhou R, Lund-Katz S, Chance B, Glickson JD & Zheng G Academic Radiology, 2004 Rationale and objectives: The purpose of this study was to define and characterize carbocyanine labeled low-density lipoprotein (LDL) to be used in the optical imaging of LDL receptorContinue Reading
Zheng G, Li H, Yang K, Blessington D, Licha K, Lund-Katz S, Chance B, Glickson JD Bioorganic & medicinal chemistry letters, 2002 DOI: 10.1016/s0960-894x(02)00193-2 For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moietyContinue Reading
Zheng G, Li H, Zhang M, Lund-Katz S, Chance B, Glickson JD Bioconjugate chemistry, 2002 DOI: 10.1021/bc025516h To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that thisContinue Reading
