Yang M, Chen J, Cao W, Ding L, Ng KK, Jin H, Zhang Z & Zheng G Nanomedicine, 2011 Research in the development of nanoscale drug carriers primarily focuses on maximizing drug delivery efficiency to tumor tissues. However, less attention has been given to minimizing drug toxicity to non-targeted cellsContinue Reading
Marotta DE, Cao W, Wileyto EP, Li H, Corbin I, Rickter E, Glickson JD, Chance B, Zheng G & Busch TM Nanomedicine, 2011 Aim: To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of humanContinue Reading
Jin H, Lovell JF, Chen J, Ng KK, Ding L, Zhang Z & Zheng G Photochemical and Photobiological Sciences, 2011 Following cellular delivery, most drugs must escape endosomes and lysosomes and reach the cytosol to be effective. This is particularly significant for nanoparticles, which can carry a large drug payload,Continue Reading
Yang M, Jin H, Chen J, Ding L, Ng KK, Lin Q, Lovell JF, Zhang Z & Zheng G Small, 2011 High-density lipoprotein (HDL)-mimicking peptide–phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability ofContinue Reading
Jin H, Lovell JF, Chen J, Ng KK, Cao W, Ding L, Zhang Z & Zheng G Cancer Nanotechology, 2010 Targeted nanoparticles have the potential to deliver a large drug payload specifically to cancer cells. Targeting requires that a ligand on the nanoparticle surface interact with a specific membrane receptorContinue Reading
Hill ML, Corbin IR, Levitin RB, Cao W, Mainprize JG, Yaffe MJ & Zheng G Academic Radiology, 2010 Rationale and Objectives: Targeted molecular probes offer the potential for greater specificity in cancer imaging with contrast-enhanced computed tomography (CT). We investigate a low-density lipoprotein (LDL) nanoparticle loaded with poly-iodinated triglyceride (ITG)Continue Reading
Zhang Z, Chen J, Ding L, Jin H, Lovell JF, Corbin IR, Cao W, Lo P, Yang M, Tsao M, Luo Q & Zheng G Small, 2010 Targeted delivery of intracellularly active diagnostics and therapeutics in vivo is a major challenge in cancer nanomedicine. A nanocarrier should possess long circulationContinue Reading
Zhang Z, Cao W, Jin H, Lovell JF, Yang M, Ding L, Chen J, Corbin I, Luo Q & Zheng G Angewandte Chemie International Edition, 2009 Getting straight to the point: A peptide–phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptakeContinue Reading
Cao W, Ng KK, Corbin I, Zhang Z, Ding L, Chen J & Zheng G Bioconjugate Chemistry, 2009 The syntheses of novel near-infrared (NIR) dyes with excellent optical properties in biological tissues have driven the continued improvement of fluorescence imaging of deeply seated tumors. Bacteriochlorophyll a (Bchl), a dye synthesizedContinue Reading
Glickson JD, Lund-Katz S, Zhou R, Choi H, Chen IW, Li H, Corbin I, Popov AV, Cao W, Song L, Qi C Molecular imaging, 2008 DOI: 10.2310/7290.2008.0012 Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of visible or near-infrared fluorescent optical and magnetic resonance imaging (MRI) contrastContinue Reading
