Huang H, Cruz W, Chen J, Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015 DOI: 10.1002/wnan.1308 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs deliveryContinue Reading
Cui L, Lin Q, Jin CS, Jiang W, Huang H, Ding L, Muhanna N, Irish JC, Wang F, Chen J & Zheng G ACS Nano, 2015 PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles’ vascular circulation by mitigating the reticuloendothelial system uptake. However, there remain many concernsContinue Reading
Lin Q, Chen J, Zhang Z, Zheng G Nanomedicine, 2014 DOI: 10.2217/nnm.13.192 RNAi therapeutics are believed to be the future of personalized medicine and have shown promise in early clinical trials. However, many physiological barriers exist in the systemic delivery of siRNAs to the cytoplasm of targeted cells to performContinue Reading
Lin Q, Jin CS, Huang H, Ding L & Zheng G Small, 2014 The abilities to deliver siRNA to its intended action site and assess the delivery efficiency are challenges for current RNAi therapy, where effective siRNA delivery will join force with patient genetic profiling to achieve optimal treatment outcome.Continue Reading
Corbin IR, Ng KK, Ding L, Jurisicova A, Zheng G Nanomedicine, 2013 DOI: 10.2217/nnm.12.137 Aim: The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer. Materials & methods: Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targetingContinue Reading
Lin Q, Chen J, Ng KK, Cao W, Zhang Z & Zheng G Pharmaceutical Research, 2013 Purpose: Molecular therapeutics often require an effective nanoparticle-based delivery strategy to transport them to cytosolic organelles to be functional. Recently, a cytosolic delivery strategy based on the scavenger receptor class B type I (SR-BI)Continue Reading
Ng KK, Lovell JF, Vedadi A, Hajian T & Zheng G ACS Nano, 2013 The abilities to deliver and subsequently activate a therapeutic at the intended site of action are two important challenges in the synthesis of novel nanoparticles. Poor tumor permeability as a result of a dense microenvironment canContinue Reading
Lin Q, Chen J, Jin H, Ng KK, Yang M, Cao W, Ding L, Zhang Z & Zheng G Nanomedicine, 2012 The main challenge for RNAi therapeutics lies in systemic delivery of siRNA to the correct tissues and transporting them into the cytoplasm of targeted cells, at safe, therapeutic levels.Continue Reading
Jin H, Chen J, Lovell JF, Zhang Z, Zheng G Israel Journal of Chemistry, 2012 DOI: 10.1002/ijch.201100054 The design and synthesis of new light‐activated contrast agents for theranostics (therapy/diagnosis) has the potential to facilitate multifunctional and improved personalized medicine. The use of light as a remote activation strategy provides spatialContinue Reading
Jin H, Lovell JF, Chen J, Lin Q, Ding L, Ng K, Pandey R, Manoharan M, Zhang Z & Zheng G Bioconjugate Chemistry, 2011 Although small interfering RNA (siRNA) can silence the expression of disease-related genes, delivery of these highly charged molecules is challenging. Delivery approaches for siRNAs are activelyContinue Reading
