Overchuk M, Damen MPF, Harmatys KM, Pomper MG, Chen J & Zheng GPhotochemistry and Photobiology, 2019DOI:10.1111/php.13181 Targeted photodynamic therapy (PDT) combined with image‐guided surgical resection is a promising strategy for precision cancer treatment. Prostate‐specific membrane antigen (PSMA) is an attractive target due to its pronounced overexpression in a variety ofContinue Reading

Luby BM & Zheng G Angewandte Chemie, 2017 DOI: 10.1002/anie.201707366 MicroRNA detection is a valuable method for determining cell identity. Molecular beacons are elegant sensors that can transform intracellular microRNA concentration into a fluorescence intensity. While target binding enhances beacon fluorescence, the degree of enhancement is insufficient for demanding applications.Continue Reading

Liu TW, Chen J, Burgess L, Wilson BC, Zheng G, Zhan L, Liu WK, & Ha BY Journal of Physical Chemistry B, 2015 Proteases play key roles in the regulation of normal cellular function, and thus, their deregulation leads to many disease states. Molecular beacons are promising protease-imaging probes forContinue Reading

Lovell JF, Chan MW, Qi Q, Chen J & Zheng G Journal of the American Chemical Society, 2011 Photodynamic therapy (PDT) stands to benefit from improved approaches to real-time treatment monitoring. One method is to use activatable photosensitizers that can both induce cell death (via singlet oxygen) and monitor itContinue Reading

Lovell JF, Jin H, Ng KK & Zheng G Angewandte Chemie International Edition, 2010 Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon resultsContinue Reading