PMB (Page 2)

Lovell JF, Jin H, Ng KK & Zheng G Angewandte Chemie International Edition, 2010 Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon resultsContinue Reading

Lovell JF, Chen J, Huynh E, Jarvi MT, Wilson BC & Zheng G Bioconjugate Chemistry, 2010 Nucleic acid photodynamic molecular beacons (PMBs) are a class of activatable photosensitizers that increase singlet oxygen generation upon binding a specific target sequence. Normally, PMBs are functionalized with multiple solution-phase labeling and purification steps.Continue Reading

Chen J, Liu TWB, Wilson BC & Zheng G Bioconjugate Chemistry, 2009 We report the proof-of-principle concept for zipper molecular beacons (ZMB) comprising an asymmetrical polyarginine/polyglutamate electrostatic “zipper” hairpin-linked fluorophore−quencher pair. The objective is to balance maximal quenching efficiency and optimal two-step activation (protease cleavage/zipper dissociation), while enhancing target cellContinue Reading

Lovell JF, Chen J, Jarvi MT, Cao W, Allen AD, Liu Y, Tidwell TT, Wilson BC & Zheng G Journal of Physical Chemistry B, 2009 The development of activatable photodynamic therapy (PDT) has demonstrated a utility for effective photosensitizer quenchers. However, little is known quantitatively about Forster resonance energy transferContinue Reading

Lo P, Chen J, Stefflova K, Warren MS, Navab R, Bandarchi B, Mullins S, Tsao M, Cheng JD & Zheng G Journal of Medicinal Chemistry, 2009 Fibroblast activation protein (FAP) is a cell-surface serine protease highly expressed on cancer-associated fibroblasts of human epithelial carcinomas but not on normal fibroblasts, normalContinue Reading

Stefflova K, Chen J Li H & Zheng G Molecular Imaging, 2006 Imaging apoptotic cells or tissues after cancer therapy in situ would be a very useful tool for assessing proper treatment conditions and therapeutic outcome. By combining therapeutic and imaging functions, we have designed a multifunctional, membrane-permeable, and cancer-specificContinue Reading