PMB (Page 3)

Photodynamic therapy agent with a built-in apoptosis sensor for evaluating its own therapeutic outcome in situ

Stefflova K, Chen J, Li H & Zheng G Journal of Medicinal Chemistry, 2006 Identifying the extent of apoptosis in cells or tissues after cancer therapy in real time would be a powerful firsthand tool for assessing therapeutic outcome. We combined therapeutic and imaging functions in one agent, choosing photodynamicContinue Reading

Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation

Chen J, Stefflova K, Niedre MJ, Wilson BC, Chance B, Glickson JD & Zheng G Journal of the American Chemical Society, 2004 We report a new concept for type-II photosensitization, based on incorporating the photosensitizer (PS) and a singlet-oxygen (1O2) quenching/scavenging molecule onto a disease-targeting linker, such that the PSContinue Reading