Porph (Page 3)

Molecular imaging in drug development: update and challenges for radiolabeled antibodies and nanotechnology

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G, Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular imagingContinue Reading

In Vivo Potential of Manganese Chelated Porphysomes as MRI Contrast Agents

Zhang CJ, Valic MS, Chen J, Zheng G STEM Fellowship Journal, 2017 DOI: 10.17975/sfj-2017-007 Porphysome nanoparticles are composed of porphyrin-conjugated lipids. The attachment of the porphyrin moiety to each phospholipid confers novel properties to the liposome-like nanoparticle, allowing it to perform a variety of diagnostic and therapeutic applications. The metalContinue Reading

Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: A pilot study

MacLaughlin CM, Ding L, Jin C, Cao P, Siddiqui I, Hwang DM, Chen J, Wilson BC, Zheng G & Hedley DW Journal of Biomedical Optics, 2016 Local disease control is a major challenge in pancreatic cancer treatment, because surgical resection of the primary tumor is only possible in a minorityContinue Reading

Controlling spatial heat and light distribution by using photothermal enhancing auto-regulated liposomes (PEARLs)

Ng KK, Weersink RA, Lim L, Wilson BC & Zheng G Angewandte Chemie International Edition, 2016 Photothermal therapy (PTT) is enhanced by the use of nanoparticles with a large optical absorption at the treatment wavelength. However, this comes at the cost of higher light attenuation that results in reduced depthContinue Reading

Nanoparticle-enabled selective destruction of prostate tumor using MRI-guided focal photothermal therapy

Jin CS, Overchuk M, Cui L, Wilson BC, Bristow RG, Chen J & Zheng G The Prostate, 2016 BACKGROUND The Magnetic Resonance Imaging (MRI)-guided focal laser therapy has shown early promise in Phase 1 trial treating low/intermediate-risk localized prostate cancer (PCa), but the lack of tumor selectivity and low efficiencyContinue Reading

Nanotexaphyrin: One-pot synthesis of a manganese texaphyrin-phospholipid nanoparticle for magnetic resonance imaging

Keca JM, Chen J, Overchuk M, Muhanna N, MacLaughlin CM, Jin CS, Foltz WD, Irish JC & Zheng G Angewandte Chemie International Edition, 2016 The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable and multifunctional chelators. However, they remain elusive asContinue Reading

Chlorosome-inspired synthesis of templated metallochlorin-lipid nanoassemblies for biomedical applications

Ng KK, Takada M, Harmatys K, Chen J & Zheng G ACS Nano, 2016 Chlorosomes are vesicular light-harvesting organelles found in photosynthetic green sulfur bacteria. These organisms thrive in low photon flux environments due to the most efficient light-to-chemical energy conversion, promoted by a protein-less assembly of chlorin pigments. TheseContinue Reading

Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging

Shakiba M, Ng KK, Huynh E, Chan H, Charron DM, Chen J, Muhanna N, Foster FS, Wilson BC & Zheng G Nanoscale, 2016 J-aggregates display nanoscale optical properties which enable their use in fluorescence and photoacoustic imaging applications. However, control over their optical properties in an in vivo setting isContinue Reading

Phototheranostic porphyrin nanoparticles enable visualization and targeted treatment of head and neck cancer in clinically relevant models

Muhanna N, Jin CS, Huynh E, Chan H, Qiu Y, Jiang W, Cui L, Burgess L, Akens MK, Chen J, Irish JC Theranostics, 2015 DOI: 10.7150/thno.13451 Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity toContinue Reading

Multimodal nanoparticle for primary tumor delineation and lymphatic metastasis mapping in a head-and-neck cancer rabbit model

Muhanna N, MacDonald TD, Chan H, Jin CS, Burgess L, Cui L, Chen J, Irish JC & Zheng G Advanced Healthcare Materials, 2015 DOI: 10.1002/ange.201803535 64Cu-porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emissionContinue Reading