Ng KK, Lovell JF & Zheng G Accounts of Chemical Research, 2011 Over hundreds of millions of years, animals have evolved endogenous lipoprotein nanoparticles for shuttling hydrophobic molecules to different parts of the body. In the last 70 years, scientists have developed an understanding of lipoprotein function, often in relationshipContinue Reading
Liu TWB, Chen J & Zheng G Amino Acids, 2010 Peptide-based molecular beacons are Förster resonance energy transfer-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets and thus are useful tools for in vivo cancer imaging. With our increasing knowledge about human genome inContinue Reading
Lovell JF, Liu TWB, Chen J & Zheng G Chemical Reviews, 2010 Photodynamic therapy (PDT) is a minimally invasive treatment that destroys target cells in the presence of oxygen when light irradiates a photosensitizer, generating highly reactive singlet oxygen. PDT has low systemic toxicity, it can emission of fluorescence. PhotosensitizersContinue Reading
Lovell JF & Zheng G Journal of Innovative Optical Health Sciences, 2008 Recent years have seen the design and implementation of many optical activatable smart probes. These probes are activatable because they change their optical properties and are smart because they can identify specific targets. This broad class of detectionContinue Reading
Stefflova K, Chen J & Zheng G Frontiers in Bioscience, 2007 Molecular beacons are essentially all probes that illuminate particular cellular target or cells with similar characteristics. In this review we focus on those molecular beacons that use near-infrared fluorescence imaging (NIRF-I) to identify the unique cellular and metabolic markersContinue Reading
Stefflova K, Chen J & Zheng G Current Medicinal Chemistry, 2007 Precisely localizing therapeutic agents in neoplastic areas would greatly improve their efficacy for killing tumor cells and reduce their toxicity to normal cells. Photodynamic therapy (PDT) is a promising cancer treatment modality, and near-infrared fluorescence imaging (NIRF-I) is aContinue Reading
