Valic MS, Hamlin M, Schimmer P & Zheng GJournal of Controlled ReleaseDOI:10.1016/j.jconrel.2020.04.002 A shared feature in the value proposition of every nanomaterial-based drug delivery systems is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of the encapsulated drug being delivered. Remarkable progress has been made towards understandingContinue Reading

Choi V, Rajora MA & Zheng GBioconjugate Chemistry, 2020DOI:10.1021/acs.bioconjchem.0c00029 Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadlyContinue Reading

Guidolin K & Zheng GACS Nano, 2019DOI:10.1021/acsnano.9b08659 Nanomedicines have historically struggled to find clinical relevance and to achieve translation successfully. In this Perspective, we discuss possible reasons for this difficulty and highlight several key features of nanomedicines that are often overlooked by biomedical engineers. We present the notion of clinicalContinue Reading

Keca JM, Zheng G Coordination Chemistry Reviews, 2019 DOI: 10.1016/j.ccr.2017.08.026 In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabledContinue Reading

Dhaliwal A, Zheng G Theranostics, 2019 DOI:10.7150/thno.37204 The enhanced permeability and retention (EPR) effect has underlain the predominant nanomedicine design philosophy for the past three decades. However, growing evidence suggests that it is over-represented in preclinical models, and agents designed solely using its principle of passive accumulation can only beContinue Reading

Valic MS & Zheng G Theranostics, 2019 DOI: 10.7150/thno.34509 A critical step in the translational science of nanomaterials from preclinical animal studies to humans is the comprehensive investigation of their disposition (or ADME) and pharmacokinetic behaviours. Disposition and pharmacokinetic data are ideally collected in different animal species (rodent and nonrodent),Continue Reading

Harmatys KM, Overchuk M & Zheng G Accounts of Chemical Research, 2019 DOI: 10.1021/acs.accounts.9b00104 The sun is the most abundant source of energy on earth. Phototrophs have discovered clever strategies to harvest this light energy and convert it to chemical energy for biomass production. This is achieved in light-harvesting complexes,Continue Reading

Lou J, Zhang L & Zheng G Advanced Therapeutics, 2019 DOI: 10.1002/adtp.201800128 Cancer immunotherapies can elicit long term, durable responses in only a fraction of patients. As such, there is a need to increase the number of patients who can benefit from cancer immunotherapies. By virtue of their versatility andContinue Reading