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Charron DM & Zheng G Nano Today, 2018 DOI: 10.1016/j.nantod.2017.12.006 Nano-bio interactions are dynamic, interrelated, and overwhelmingly influence nanomedicine efficacy. Molecular imaging techniques such as fluorescence are essential for illuminating the nano-bio interface to guide nanomedicine development. With advances in reliable labelling of nanoparticles with fluorophores, integrated Förster resonance energyContinue Reading

Pellow C, Goertz DE & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017 DOI: 10.1002/wnan.1502 The development of encapsulated microbubbles (~1–6 μm) has expanded the utility of ultrasound from soft tissue anatomical imaging to not only functional intravascular imaging, but therapeutic interventions, with compelling studies of elicited biological effects. TheContinue Reading

Rajora MA, Lou JWH & Zheng G Chemical Society Reviews, 2017 DOI: 10.1039/C7CS00525C Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity.Continue Reading

Overchuk M & Zheng G Biomaterials, 2017 DOI: 10.1016/j.biomaterials.2017.10.024 Despite rapid advancements in the field of nanotechnology, there is mounting frustration in the scientific community regarding the translational impact of nanomedicine. Modest therapeutic performance of FDA-approved nanomedicines combined with multiple disappointing clinical trials (such as phase III HEAT trial) haveContinue Reading

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G, Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. Molecular imagingContinue Reading

Colombo I, Overchuk M, Chen J, Reilly RM, Zheng G & Lheureux S Methods, 2017 DOI: 10.1016/j.ymeth.2017.07.018 Despite the significant advancement achieved in understanding the molecular mechanisms responsible for cancer transformation and aberrant proliferation, leading to novel targeted cancer therapies, significant effort is still needed to “personalize” cancer treatment. MolecularContinue Reading

Rajora MA & Zheng G Frontiers in Pharmacology, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancerContinue Reading

Luby BM, Charron DM, MacLaughlin CM & Zheng G Advanced Drug Delivery Reviews, 2016 Molecular imaging has emerged as an indispensable technology in the development and application of drug delivery systems. Targeted imaging agents report the presence of biomolecules, including therapeutic targets and disease biomarkers, while the biological behaviour ofContinue Reading

Huang H, Cruz W, Chen J, Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015 DOI: 10.1002/wnan.1308 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs deliveryContinue Reading