Charron DM, Chen J & Zheng G Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer, 2015 Disease heterogeneity within and between patients necessitates a patient-focused approach to cancer treatment. This exigency forms the basis for the medical practice termed personalized medicine. An emerging, important component of personalized medicineContinue Reading
Ng KK & Zheng G Chemical Reviews, 2015 Optical and photonic technologies play an important role in human progress. The bending of light to our will has not only enabled our biological self-discovery, but has also allowed us to probe and investigate the natural life around us. These advancements haveContinue Reading
Huang H, Cruz W, Chen J & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2014 Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages for drugs delivery overContinue Reading
Lin Q, Chen J, Zhang Z, Zheng G Nanomedicine, 2014 DOI: 10.2217/nnm.13.192 RNAi therapeutics are believed to be the future of personalized medicine and have shown promise in early clinical trials. However, many physiological barriers exist in the systemic delivery of siRNAs to the cytoplasm of targeted cells to performContinue Reading
MacDonald TD, Zheng G Photonics & Lasers in Medicine, 2014 DOI: 10.1515/plm-2013-0059 Porphysomes are an emerging class of photonic nanoparticles formed from the self-assembly of porphyrin-lipid conjugates. They retain the multifunctional properties of their porphyrin building blocks but also have unique properties emerging from the nanostructure itself. Porphysomes are able to actContinue Reading
Huynh E & Zheng G NanoToday, 2014 The traditional role of lipids in the generation of lipid-based supramolecular structures has predominantly been to serve as building blocks to support the delivery or stabilization of a molecule or structure. With an introduction to the synthesis of porphyrin-lipid, a porphyrin conjugated toContinue Reading
Huynh E & Zheng G Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013 Multifunctional nanoparticles have been developed to overcome the conventional hurdles associated with the diagnosis and treatment of disease. However, there are often caveats involved with the development and clinical translation of multifunctional nanoparticles largely regarding the notion thatContinue Reading
Jin H, Chen J, Lovell JF, Zhang Z, Zheng G Israel Journal of Chemistry, 2012 DOI: 10.1002/ijch.201100054 The design and synthesis of new light‐activated contrast agents for theranostics (therapy/diagnosis) has the potential to facilitate multifunctional and improved personalized medicine. The use of light as a remote activation strategy provides spatialContinue Reading
Roxin A & Zheng G Future Medicinal Chemistry, 2012 Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long-standing focus within peptide research is the creation of structurally constrained peptides generated through cyclization. Cyclization isContinue Reading
Jin CS & Zheng G Lasers in Surgery and Medicine, 2011 Background and Objective: In photodynamic therapy (PDT), photosensitizers are activated by light of a specific wavelength and produce cytotoxic molecules to damage diseased tissues. Most photosensitizers are hydrophobic and easily aggregate in aqueous solution. To maintain their photodynamic activityContinue Reading
